primary immunodeficiencies constitute a group of highly complex congenital disorders most of which are characterized by a very poor prognosis. allogeneic hematopoietic stem cell transplantation (hsct) has become an established curative treatment approach in many of these disorders, which may be permanently corrected. in this presentation basic and practical aspects of hsct are presented, with a...

Wernicke's encephalopathy is a metabolic disorder caused by thiamine deficiency, and characterized acute mental confusion, ophthalmoplegia ataxia. Its due to nutritional deficiency arising from prolonged illness affecting nutrition of the patient or requiring parenteral for duration, debilitating chronic illnesses like solid organ lymphoid malignancies. It has been commonly seen alcoholics who ...

the aim of this study was to determine the incidence and causes of fever as a major problem contributing to transplantation related mortality among patients undergoing hematopoietic stem cell transplantation (hsct) and evaluation of antibiotic use, according to reliable guidelines.we retrospectively reviewed hospital records of 195 adult patients who underwent hsct between 2009-2011 at hematolo...

Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative option for patients with acute myeloid leukemia (AML). Our understanding of the biology of leukemic stem cells has continued to improve over the last decade and risk stratification using cytogenetics and molecular markers have improved our ability to select patients who would benefit from allogeneic transplantat...

Allogeneic haematopoietic stem cell transplantation (allo-HSCT) patients experience several problems, such as physical, psychological, and psychosocial side effects, during the transplantation phase. Physical exercise has recently been proposed as a method that assists HSCT patients in their recovery from the decline in physical fitness, worsening of psychological status, and impaired quality o...

Selection of an HLA identical donor is a critical pre-requisite for successful hematopoietic stem cell transplantation (HSCT). Most transplant centers utilize blood as the most common source of DNA for HLA testing. However, obtaining blood through phlebotomy is often challenging in patients with conditions like severe leucopenia or hemophilia, pediatric and elderly patients. We have used a simp...

Recipients of hematopoietic stem cell transplantation (HSCT) are at substantial risk of bacterial, fungal, viral, and parasitic infections depending on the time elapsed since transplantation, presence of graft-versus-host disease (GVHD), and the degree of immunosuppression. Infectious complications in HSCT recipients are associated with high morbidity and mortality. Bacterial infections constit...

Hematopoietic stem cell transplantation (HSCT) is an established therapeutic procedure for several congenital and acquired disorders, both malignant and nonmalignant. Despite the great improvements in HSCT clinical practices over the last few decades, complications, such as graft vs. host disease (GVHD) and sinusoidal obstructive syndrome (SOS), are still largely unpredictable and remain the ma...

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective and sometimes the only curative therapy for patients with certain hematological diseases. Allo-HSCT has been practiced in China for approximately 30 years, and great improvements have been made within the past decade, particularly in fields such as the haploidentical HSCT system, strategies to overcome relapse and GV...

Low-DoseDecitabine for PatientsWith Thrombocytopenia Following Allogeneic Hematopoietic StemCell Transplantation: A Pilot Therapeutic Study Isolatedthrombocytopeniaafterhematopoietic stemcell transplantation (HSCT) isdefinedasconsistently lowplatelet counts after transplantation,withrecoveryofallotherperipheralblood cell lines.1 It represents a challenging clinical problem because itoften leads...