OBJECTIVE Our purpose was to apply arterial spin labeling (ASL) magnetic resonance imaging (MRI) to characterize regional cerebral blood flow (rCBF: the CBF values at each voxel / the subject's mean global flow) in patients with transient hypothyroidism after thyroidectomy. METHODS Our study included 27 patients who had undergone total thyroidectomy due to thyroid cancer and pre-131I therapy ...

BACKGROUND Thyroid hormone treatment in children with congenital hypothyroidism can prevent intellectual disability. Guidelines recommend that children diagnosed with congenital hypothyroidism through newborn screening remain on treatment to at least 3 years of age, after which a trial off therapy can determine which children have transient hypothyroidism. The purpose of this study was to descr...

We measured free thyroxin (FT4) in dried blood samples from 10 000 euthyroid and 29 hypothyroid newborns (three with transient hypothyroidism and 26 permanent). In euthyroids, the mean FT4 concentration was 16.9 (SD 4.5) pmol/L. Preterm babies had low concentrations of FT4, and values were closely related to birth weight when less than 2500 g. Assay of blood-spot FT4 appears to be specific as a...

Congenital hypothyroidism is one of the causes mental retardation in children that can be prevented if recognized and treated early. Thyroid hormones play a role development central nervous system. It known 95% CH do not show typical clinical signs symptoms at birth duration early intervention to prevent short. Therefore, most developed countries have conducted neonatal screening programs for d...

BACKGROUND Diagnostic re-evaluation is important for all patients with congenital hypothyroidism (CH) for determining the etiology and identifying transient CH cases. Our study is a first thyroxine therapy withdrawal study conducted in Macedonian CH patients for a diagnostic re-evaluation. We aimed to evaluate the etiology of CH, the prevalence of transient CH and identify predictive factors fo...

BACKGROUND: Involvement of the thyroid gland is an important morbidity of therapy for Hodgkin's disease, which should be well recognized by caretakers of these patients. However, the roles of age at the time of therapy for Hodgkin's disease, chemotherapy, treatment with reduced dose of radiation and lymphangiography in causing thyroid abnormalities have not been defined. MATERIALS AND METHODS: ...

Testis is very rich in unsaturated fatty acids with poor antioxidant defense system and due to presence of a potential reactive oxygen species (ROS)-generating systems, it is much more vulnerable to oxidative damage than other tissues. Thyroid hormones are well known to regu la te s te ro idogenes is and spermatogenesis, thereby, affecting male fertility. In the presence of disturbed thyroid co...

Transient neonatal 6-propyl-2-thiouracil (PTU) induced hypothyroidism affects Leydig and Sertoli cell numbers in the developing testis, resulting in increased adult testis size. The hypothyroid condition was thought to be responsible, an assumption questioned by studies showing that uninterrupted fetal/postnatal hypothyroidism did not affect adult testis size. Here, we investigated effects of t...