Multiple hereditary exostoses is an autosomal dominant skeletal disorder in which there are numerous cartilage-capped excrescences in areas of actively growing bone. The condition is genetically heterogeneous, and at least three genes, ext1, ext2 and ext3 are involved. The reported risk for malignant transformation to chondrosarcoma has been from 0.6% to 2.8%. We have reviewed six generations o...

Overall persistence (POV) and long-range transport potential (LRTP) of and endosulfan and two of their transformation products, endosulfan sulfate and endosulfan diol, are estimated with two multimedia box models, the OECD POV and LRTP Screening Tool and the global, latitudinally resolved model CliMoChem. The OECD Tool yields POV and LRTP for each compound separately, whereas the CliMoChem mode...

Signal transducers and activators of transcription (STATs) belong to a family of transcription factors that were originally identified as mediators of cytokine-induced gene expression. Recent evidence, however, has shown that certain members of the STAT family, including STAT3, are also involved in cellular transformation. Here we show that STAT5 also plays a role in cellular transformation by ...