The aim of the present study was to develop and investigate the feasibility of delivering Nebivolol as a transdermal patch by iontophoresis. The passive and electrically assisted transdermal delivery of Nebivolol hydrochloride by iontophoresis will improve the therapeutic efficacy and overcome the difficulties raised in oral drug delivery. Because of its extensive hepatic metabolism and low dos...

Transdermal administration of drugs is generally limited by the barrier function of the skin. Colloidal systems are one of the most contentious methods for transdermal delivery of active substances across the skin. The colloidal systems helps in overcoming the shortcomings associated with transdermal drug delivery systems and provide sustained and controlled release of drugs. This review presen...

Fentanyl, a surgical analgesic and general anaesthetic, is a lipophilic short-acting synthetic opioid, having a selective potent effect on mu receptors. The transdermal therapeutic fentanyl-system (TTS-F) allows for a continued and sustained titratable amount of fentanyl to be delivered without the inconvenience of the typical 24-h administration of other analgesics. Although incidences of resp...

Delivery of drugs through the skin has been always a challenging area for research due to barrier properties exhibit by the outermost layer of skin stratum corneum. In the last two decades, the transdermal drug delivery system has become a proven technology that offers significant clinical benefits over other dosage forms. Because transdermal drug delivery offers controlled as well as predeterm...

Rotigotine, a nonergot dopamine agonist, has been developed as a novel transdermal formulation. The rotigotine transdermal patch has received EMA and FDA marketing authorization for the treatment of adult patients with early or advanced Parkinson’s disease or with moderate-to-severe restless legs syndrome (RLS). This review comprises an overview of the pharmacokinetics, the pharmacodynamics and...

BACKGROUND Cigarette smoking has been shown to adversely affect heart rate variability (HRV), suggesting dysregulation of cardiac autonomic function. Conversely, smoking cessation is posited to improve cardiac regulation. PURPOSE The aim of the present study was to examine the effects of smoking cessation on HRV among a community sample of chronic smokers. METHODS Sixty-two healthy male smo...

Transdermal Drug Delivery System (TDDS) is described as a self-contained or discrete dosage form that applied to the intact skin. This rout of drug administration drugs through skin for therapeutic use an alternative approach oral, intravascular, subcutaneous, and transmucosal routes. The delivery systemic circulation provides convenient route variety clinical indications. allows continuous adm...

INTRODUCTION: The age-old theory that imparted the status of “dead, impermeable barrier devoid of biological activity” to skin had already been challenged by the development of pioneering transdermal product, but a less than impressive commercial growth in this sector had raised some doubts about the feasibility of this route as an efficient device of drug delivery. The journey of transdermal r...

      The present study was performed to explore the matrix property of Ficus glomerata fruit mucilage for making transdermal patches. The mucilage was evaluated for its physicochemical properties. Various transdermal patches of indomethacin were prepared by solvent evaporation technique using different proportions of F. glomerata fruit mucilage. The compatib...

Transdermal patches are a popular route for drug delivery because of the sustained drug levels, low side effects, reduced hepatitic first-pass effect and ease of use, including self– administration. The basic components of any transdermal delivery system include one or more active pharmaceutical ingredient s (APIs) dissolved or dispersed in a reservoir or inert polymer matrix; an outer backing ...