The TOL plasmid pWW53 encodes a catabolic pathway for the metabolism of toluene. It bears an upper-pathway operon for the oxidation of toluene to benzoate and a copy of the gene that encodes regulatory protein XylR. For metabolism of the aromatic carboxylic acid, it bears two functional homologous meta-pathway operons, together with two functional copies of the xylS regulatory gene (xylS1 and x...

ABSTRACT The balance between stem cell potency and lineage specification entails the integration of both extrinsic intrinsic cues, which ultimately influence gene expression through activity transcription factors. One example this is provided by Hippo signalling pathway, plays a central role in regulating organ size during development. pathway mediated transcriptional co-factors Yes-associated ...

Colon cancer frequently results from mutations that constitutively activate the Wnt signaling pathway, a major target being the tumor suppressor gene adenomatous polyposis coli (APC). We recently identified the transcription factor RIP140 as a new inducer of APC gene transcription that inhibits colon cancer cell growth and impedes the Wnt signaling pathway by reducing β-catenin activation.

Citation: Zhao Q, Xiang X, Liu D, Yang A and Wang Y (2018) Tobacco Transcription Factor NtbHLH123 Confers Tolerance to Cold Stress by Regulating the NtCBF Pathway and Reactive Oxygen Species Homeostasis. Front. Plant Sci. 9:381. doi: 10.3389/fpls.2018.00381 Tobacco Transcription Factor NtbHLH123 Confers Tolerance to Cold Stress by Regulating the NtCBF Pathway and Reactive Oxygen Species Homeost...

Pathway analysis has been extensively applied to aid in the interpretation of the results of genome-wide transcription profiling studies, and has been shown to successfully find associations between the biological phenomena under study and biological pathways. There are two widely used approaches of pathway analysis: over-representation analysis, and gene set analysis. Recently genome-wide tran...

The tumor microenvironment, especially the extracellular matrix (ECM), is strongly associated with cell proliferation and metastasis. Numerous studies have provided evidence suggesting that fibronectin (FN) in ECM supports cancer escape contributes to migration, resulting distant metastasis poor outcomes patients. In our study, it was demonstrated FN expression elevated tissues from highly mali...