extract   until recent years pharmacological researches focused on pathogeneses and abnormality in organogenesis but now researchers are studying drugs physiological disorders in pregnancy. these studies are specially focused on mothers and fetus, regulatory mechanism of passing drugs through placenta and movement of drug' materials between barriers of milk and blood in the breast. also th...

introduction: since prescription is a way of communication between the pharmacist, physician and patient, inattention to its principles may result in mis-consumption or incomplete use of the medicine, drug interactions, and increased probable adverse effects. therefore, this research tried to investigate physicians' commitment to principles of prescription writing for outpatients insured by med...

Aim: The aim of the study was to determine the prevalence, approach and behavior towards medication storage & self-medication practice amongst the youth in Karnataka, India. Methodology: A pre-cross sectional survey was conducted, administering a pre-piloted questionnaire among the target population. Sample size of 150 was analyzed using the percentage method. Results: Out of 150 respondents, 8...

OBJECTIVE To estimate the prevalence of one month psychotropic drug use in São Paulo, Brazil, and to assess the gap treatment between the presence of mental disorders and psychotropic drug users. METHOD A probabilistic sample of non-institutionalized individuals from the general population of São Paulo (n = 2336; turnout: 84.5%) who were 15 years or older were interviewed by a trained researc...

BACKGROUND Some psychotropic medications (e.g., benzodiazepines, sedative antidepressants, etc.) may impair cognitive and psychomotor functions and, therefore, endanger traffic safety (Ravera, Br J Clin Pharmacol, 72(3):505-513, 2011). They affect detection, registration, and information processing, problem solving, and decision-making processes, and they also affect emotional and social aspect...

F years ago this month, President John F. Kennedy signed into law the Kefauver– Harris Amendments to the Federal Food, Drug, and Cosmetic Act (see photo). With the stroke of a pen, a threadbare Food and Drug Administration (FDA) was given the authority to require proof of efficacy (rather than just safety) before approving a new drug — a move that laid the groundwork for the phased system of cl...

In the foreword to this book, the first of a proposed ten-volume series, the editors state that "Physiological Pharmacology is designed to be an authoritative account of the effects of drugs on physiological systems;" that a need exists for such a work cannot be denied. Volume 1 forms the first of a three-part account of the nervous system and embodies the contributions of thirteen authors. It ...

The aim of the present study was to compare the effect of (detomidine 150 mg/kg) mixed (Ketamine 35mg/kg) in one syringe with (Acepromazine 2mg. /Kg B. W.) mixed (Ketamine 35mg/kg) in one syringe. First protocol uses detomidine and Ketamine in one syringe administered intramuscularly and the second protocol uses acepromazine and ketamine in one syringe administered intramuscularly. Data were co...

Atypical antipsychotics are also used in the treatment of anxiety-related disorders. Clinical and preclinical evidence regarding their intrinsic anxiolytic efficacy has been mixed. In this study, we examined the potential anxiolytic-like effects of risperidone and olanzapine, and compared them with haloperidol, chlordiazepoxide (a prototype of sedative-anxiolytic drug) or citalopram (a selectiv...

BACKGROUND: Prescription drug misuse among young adults is increasingly viewed as a public health concern, yet most research has focused on student populations and excluded high-risk groups. Furthermore, research on populations who report recent prescription drug misuse is limited. This study examined patterns of prescription drug misuse among high-risk young adults in Los Angeles (LA) and New ...