The anti-allergic drug tranilast (TNL) reportedly exhibits inhibitory activity against epithelial-mesenchymal transition (EMT) at high concentrations. Herein, we synthesized a new hybrid molecule, tyrosine-conjugated TNL having propyl linker (TNL-T), which is expected to increase anti-EMT by enhancing intracellular delivery through an amino acid transporter expressed in cancer cells. of TNL-T w...

Orofacial granulomatosis (OFG) is an uncommon disorder characterized by persistent enlargement of the soft tissues lips, oral mucosa, and area around mouth. It has uncertain etiology, but relationship with metal allergy, odontogenic infection, Crohn’s disease been reported. We report on 24 patients OFG we experienced in past 19 years between 2004 2022. They were all diagnosed histological exami...