conclusion both techniques provided quantitatively consistent results of in vivo velocity vector fields in right internal carotid artery (rca). pc mri represented a good estimation of main flow patterns inside the vasculature, which seems to be acceptable for clinical use. however, limitations of each technique should be considered while interpreting results. subjects and methods mr imaging was...

Thyroid hormone (TH) exerts its effects by binding to the thyroid hormone receptor (TR), which binds to TH response elements (TREs) to regulate target gene expression. We investigated the relative ability of liganded homodimers TR and retinoid X receptor (RXR), and the heterodimer TR/RXR, to regulate gene expression for the TRE half-site organizations: direct repeat 4 (DR4), inverted repeat 0 (...

Esaki, Takanori, Hideyo Suzuki, Michelle Cook, Kazuaki Shimoji, Sheue-Yann Cheng, Louis Sokoloff, and Jacques Nunez. Cardiac glucose utilization in mice with mutated and -thyroid hormone receptors. Am J Physiol Endocrinol Metab 287: E1149–E1153, 2004. First published August 10, 2004; doi:10.1152/ajpendo.00078. 2004.—Abnormal thyroid function is usually associated with altered cardiac function. ...

Weiss, Roy E., Claudia Korcarz, Olivier Chassande, Kevin Cua, Peter M. Sadow, Eugene Koo, Jacques Samarut, and Roberto Lang. Thyroid hormone and cardiac function in mice deficient in thyroid hormone receptoror : an echocardiograph study. Am J Physiol Endocrinol Metab 283: E428–E435, 2002; 10.1152/ajpendo.00019. 2002.—We investigated the effect of thyroid hormone (TH) receptor (TR) and isoforms ...

The thyroid hormone receptor (TR) has the dual ability to activate or repress transcription of specific genes. A cell-free transcription system was used to study the effects of TR on transcription by positively (TREpMLP) and negatively (TSH alpha) regulated promoters. Receptor-deficient HeLa cell extracts were complemented with baculovirus-produced TR. TR stimulated transcription from the TREpM...

This study was undertaken to determine the following: 1) the kinetic changes responsible for the depletion and repletion of plasma transferrin (Tr) concentration in children with protein-energy malnutrition (PEM); 2) the role of infection in mediating these changes; and 3) whether plasma Tr concentration is related to body protein status. We measured plasma Tr concentration, and fractional (FSR...

The current review focuses on the molecular mechanisms and developmental roles of thyroid hormone receptors (TRs) in gene regulation and metamorphosis in Xenopus laevis and discusses implications for TR function in vertebrate development and diversity. Questions addressed are: (1) what are the molecular mechanisms of gene regulation by TR, (2) what are the developmental roles of TR in mediating...

A series of molybdenum(VI) oxide-organic solids were prepared by hydrothermal reactions employing N-donor tectons, which combine two 1,2,4-triazol-4-yl sites separated by representative aliphatic spacers (ethylene, tr(2)eth; 1,3-propylene, tr(2)pr; trans-1,4-cyclohexanediyl, tr(2)cy; diamondoid 1,3-adamantanediyl, tr(2)ad; 1,6- and 4,9-diamantanediyls, 1,6-tr(2)dia and 4,9-tr(2)dia) and heterof...

Serine protease inhibitor elafin (E) and its precursor, trappin-2 (Tr), have been associated with mucosal resistance to HIV-1 infection. We recently showed that Tr/E are among principal anti-HIV-1 molecules in cervicovaginal lavage (CVL) fluid, that E is ∼130 times more potent than Tr against HIV-1, and that Tr/E inhibited HIV-1 attachment and transcytosis across human genital epithelial cells ...