OBJECTIVE To determine the effects of total parenteral nutrition (TPN) and enteral nutrition (EN) on biochemical and clinical outcomes in pancreatic cancer patients who underwent pancreaticoduodenectomy. METHODS From the year 2006 to 2008, 60 patients who underwent pancreaticoduodenectomy in Tianjin Third Central Hospital were enrolled in this study. They were randomly divided into the EN gro...

PURPOSE The aim was to compare preventive effect of total parenteral nutrition (TPN) and oral nutrition (preOp) on the perioperative insulin resistance prevention in surgical gastrointestinal cancer patients. MATERIAL/METHODS The study was conducted in a group of 75 elective gastric and large intestine cancer patients. Patients were randomly divided into 3 study groups, 25 patients each: grou...

HYPOTHESIS The levels of intestinal interleukin 10 and interleukin 4, inhibitors of intercellular adhesion molecule-1 (ICAM-1) expression, decline with total parenteral nutrition (TPN). These cytokine changes induced by lack of enteral nutrition may increase ICAM-1 expression, resulting in polymorphonuclear neutrophil accumulation in intestine. DESIGN Prospective randomized experimental trial...

Over 30,000 patients are permanently dependent on Total Parenteral Nutrition (TPN) for survival with several folds higher requiring TPN for a prolonged duration. Unfortunately, it can cause potentially fatal complications. TPN infusion results in impairment of gut mucosal integrity, enhanced inflammation, increased cytokine expression and trans-mucosal bacterial permeation. It also causes endot...

Triphosphopyridine nucleotide serves as the primary hydrogen or electron acceptor in a variety of biological oxidations. Some dehydrogenases like glucose g-phosphate dehydrogenase (1) and isocitric acid dehydrogenase (2) have an absolute requirement for TPN. Other systems such as liver glutamic acid dehydrogenase (3, 4) can utilize either TPN or DPN about equally well. In addition, a large numb...

BACKGROUND In our previous study, we reported that early postoperative oral feeding accelerated upper gastrointestinal anastomotic healing in rats. To investigate its underlying mechanism, we performed in vivo and in vitro experiments. MATERIALS AND METHODS Rats that received proximal jejunal anastomosis were divided into four groups: the enteral nutrition (EN) group were fed via gastrostomy,...

Von Euler and Vestin (1) demonstrated the synthesis of triphosphopyridine nucleotide (TPN) when diphosphopyridine nucleotide (DPN) was incubated with adenosine triphosphate (ATP) in the presence of crude yeast maceration juice. In subsequent reports (2) from the Stockholm laboratory, several mechanisms for this reaction were considered but none was established. With crude pigeon liver fractions...

Triphosphopyridine nucleotide serves as the primary hydrogen or electron acceptor in a variety of biological oxidations. Some dehydrogenases like glucose g-phosphate dehydrogenase (1) and isocitric acid dehydrogenase (2) have an absolute requirement for TPN. Other systems such as liver glutamic acid dehydrogenase (3, 4) can utilize either TPN or DPN about equally well. In addition, a large numb...

Abstract. This letter investigates the epidemic spreading in two-vectors propagation network (TPN). We propose detailed theoretical analysis that allows us to accurately calculate the epidemic threshold and outbreak size. It is found that the epidemics can spread across the TPN even if two sub-single-vector propagation networks (SPNs) of TPN are well below their respective epidemic thresholds. ...

The purpose of this study was to determine in a randomized, prospective manner whether administration of total parenteral nutrition (TPN) via multilumen catheters increases the risk of catheter-related sepsis (CRS). All patients receiving hyperalimentation during a 24-month period were randomized to receive either a double-lumen catheter (DLC) or a triple-lumen catheter (TLC). A total of 101 ca...