نتایج جستجو برای: toxin conjugate
تعداد نتایج: 92714 فیلتر نتایج به سال:
BACKGROUND Vibrio cholerae is the cause of cholera, a severe watery diarrhea. Protection against cholera is serogroup specific. Serogroup specificity is defined by the O-specific polysaccharide (OSP) component of lipopolysaccharide (LPS). METHODOLOGY Here we describe a conjugate vaccine for cholera prepared via squaric acid chemistry from the OSP of V. cholerae O1 Inaba strain PIC018 and a re...
Curcumin is the natural bio-active component of turmeric (Curcuma longa L.) with known therapeutic properties; nevertheless, its biological applications are limited due to its poor bioavailability. To overcome this limitation, curcumin was conjugated with silica nanoparticles. Curcumin was separated from turmeric by microwave-assisted extraction and silica nanoparticles were developed from rice...
S.typhimurium is a gram negative bacterium causing serious enteric or extraintestinal infections in human, cattle and birds. These kinds of infections may lead to some permanent or nonpermanent complications like endophthalmitis, Guillain-Barre syndrome and osteomyelitis . Multi-resistant strains of S.typhimurium have been reported from several countries, and these infections are a major public...
Global Krylov subspace methods are the most efficient and robust methods to solve generalized coupled Sylvester matrix equation. In this paper, we propose the nested splitting conjugate gradient process for solving this equation. This method has inner and outer iterations, which employs the generalized conjugate gradient method as an inner iteration to approximate each outer iterate, while each...
Cholera outbreak is more common in developing countries. The causative agent of the disease is Vibrio cholerae strains O1 and O139. Traditional diagnostic testing for Vibrio is not always reliable, because Vibrio can enter a viable but non cultivable state. Therefore, nucleic acid-based tests have emerged as a useful alternative to traditional enrichment testing. In this investigation, a...
designing and producing a proper fusion construction is the most important problem of producing large quantities of a properly folded functional protein. this construction should have all necessary components of a real gene. a good designed fusion gene construction could be cloned into a good and suitable host. clostridium perfringens is an important pathogen of humans and livestock and produce...
aflatoxins are a group of fungal toxic metabolites, which are contaminated certain food commodities. elisa is one of the sensitive methods for detection of aflatoxins. preparation and stabilizing of a proper conjugated tracer for detection of aflatoxins is probably the main step for designing an elisa method. in current study, different stabilizers were applied to stabilize a newly prepared con...
[5] Chuang YC, Chiang PH, Huang CC, Yoshimura N, Chancellor MB. Botulinumtoxin typeA improvesbenignprostatic hyperplasia symptoms in patients with small prostates. Urology 2005;66:775–9. [6] Doggweiler R, Zermann DH, Ishigooka M, Schmidt RA. Botoxinduced prostatic involution. Prostate 1998;37:44–50. [7] Lin ATL, Yang AH, Chen K-K. Effects of botulinum toxin A on the contractile function of dog ...
ABSTRACT Most of physiological effects of bradykinin is due to its effect on bradykinin B2 receptors. There is no reports of preparation of a photoactivatable analogue of bradykinin reactive with sloubilized bradykinin B2 recpetors. Photoactivatable radioactive ligands are powerful tools in purification of receptors. In this study we report preparation of a photoactivatable iodinatable analo...
We have utilized a new class of acid-cleavable protein cross-linking reagents in the construction of antibody-diphtheria toxin conjugates (Srinivaschar, K., and Neville, D. M., Jr. (1989) Biochemistry 28, 2501-2509). The potency of anti-CD5 conjugates assayed by inhibition of protein synthesis on CD5 bearing cells (Jurkat) is correlated with cross-linker hydrolytic rates. The maximum increase i...
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