• Receptor and cell-based bioassays provided important insights into sediment toxicity. The included nine stress-activated receptors from fish. Chemical analyses of extracts revealed complex contamination profiles. Bioassays can be great importance for future environmental risk assessment. A luciferase reporter gene-based bioassay battery consisting fish, complemented with traditional fish bioa...

Identification of tetrodotoxin (TTX) and its derivatives produced from a Vibrio strain in the intestine of the puffer fish Fugu vermicularis radiatus was performed by thin-layer chromatography, electrophoresis, high-performance liquid chromatography, and gas chromatography-mass spectrometry, together with a mouse bioassay for toxicity. It was demonstrated that the isolated bacterium produced TT...

The galactolipid (2S)-1,2-di-O-[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl]-3-O-beta-d-galactopyranosyl glycerol (1) isolated from dried and milled fruits of Rosa canina by bioassay-guided fractionation is an antiinflammatory agent with inhibitory effects on chemotaxis of human peripheral blood neutrophils in vitro. The inhibition of cell migration is not related to toxicity. The presence of 1 in r...

The present investigation was undertaken to investigate the acute toxicity of cadmium, a heavy metal widely detected in aquatic environment due natural effects and anthropogenic activities, freshwater teleost, Channa punctata (Bloch). experiments for bioassay were performed semi-static test condition according standard guidelines. behavioural changes fish observed all tested concentrations meta...

This study examined the effectiveness and repellency value of commercial insecticide initial “KB” (Deltamethrin [0.6%]) to German cockroaches. The research was performed by contact toxicity repellent bioassay method using two populations; VCRU-WHO RMKN-BKT. criteria are based on knockdown time (KT) lethal (LT) that refers Directorate Fertilizers Pesticides Indonesia, 2004. Results demonstrated ...

The median lethal dose (LD 50 ) and low 10 are calculated in acute toxicity studies, as well during specific activity assessment of some medicines. aim the study was to develop a procedure for using CombiStats calculate LD . authors proposed step-by-step algorithm processing bioassay results biometric software (median effective determination model, probit analysis) with conversion doses simple ...

The review summarizes studies on the detoxification effects of water-soluble humic substances (HS), which are products natural transformation organic in soils and bottom sediments that serve as detoxifying agents water solutions. HS microorganisms quite complex: neutralize free pollutants (indirect bioeffects) also stimulate protective response organisms (direct bioeffects). Prospects potential...

Acute toxicity of commercial grade organophosphate insecticide, quinalphos (25% emulsified concentration) to common carp (Cyprinus carpio) was tested through bioassay. The acute toxicity of quinalphos to the fingerlings exposed for 96 hr was found to be 2.75 ppm. For sub lethal toxicity study, the fish were exposed to two concentration viz., 1/10th of LC50 (0.275 ppm) and 1/5th of LC50 (0.55 pp...

Accurate prediction of the adverse effects of test compounds on living systems, detection of toxic thresholds, and expansion of experimental data sets to include multiple toxicity end-point analysis are required for any robust screening regime. Alamar Blue is an important redox indicator that is used to evaluate metabolic function and cellular health. The Alamar Blue bioassay has been utilized ...