Background: Psoriasis is an autoimmune and common disease that affects 1 to 3% of the world’s population. The appearance progress psoriasis are influenced by genetic environmental factors. Topical steroids have remained first-line treatment for psoriasis. Long-term use topical corticosteroids associated with risk side effects. purpose this study was compare complications efficacy clobetasol oin...

A 48-year old female, with no relevant history of morbidity, consulted for symptoms of 3-month evolution of pruritic lesions located on the left side of the body that had been growing progressively. A physical examination found evidence of hyper-pigmented and hyperkeratotic papules that had coalesced into plaques on the abdomen, hip and upper part of the left thigh. The lesions did not go above...

Oral Lichen Planus (OLP) is a chronic inflammatory disease of oral mucosa, with an immunological origin. Atrophic/erosive OLP needs appropriate treatment, due to the pain and malignancy potential. Topical corticosteroids are the most effective drug therapy and mouthwashes are more effective topical dosage forms for this purpose. However, at present there are no corticosteroid mouthwashes availa...

Oral Lichen Planus (OLP) is a chronic inflammatory disease of oral mucosa, with an immunological origin. Atrophic/erosive OLP needs appropriate treatment, due to the pain and malignancy potential. Topical corticosteroids are the most effective drug therapy and mouthwashes are more effective topical dosage forms for this purpose. However, at present there are no corticosteroid mouthwashes availa...

In a survey on work-related skin problems in professional ice hockey players one player developed a severe patch test reaction with an unexpected complication. The positive reaction to diethyl thiourea was vesiculo-bullous, oedematous and significantly elevated and a spreading several centimeters outside the test area was noted. Starting less than 24h after the patch test application, itching e...

REPORT OF A CASE A 22-year-old man with history of acne was referred to our dermatology department for possible patch testing and evaluation of his widespread rash. Three months before referral, the patient had an eruption of well-demarcated plaques on his scalp, face, neck, and extremities, associated with pruritus. The patient’s eruption was refractory to topical corticosteroids (desoximetaso...

Lycopene is a hydrocarbon phytochemical that present in red vegetables and fruits, several studies reviewed the pharmacological properties of across years ago different aspects including inflammation, cardiovascular disease, prostatic cancer dermatological complaints. Objective: we investigated potential impact two doses topical as add on therapy to Clobetasol Psoriasis model induced by Imiquim...

Cip-interacting zinc finger protein 1 (Ciz1) stimulates DNA replication and has been implicated in the tumorigenesis of breast cancer cells. In order to investigate the possibility of using medicinal glucocorticoids against breast cancer, we studied whether certain glucocorticoids affect the expression of Ciz1. The in vitro effect of clobetasol tr...