introduction pharmacologic treatment of radicular pain with oral medications is limited by adverse effects and concern for dependence. while topical formulations have been explored in pain research, there is no published literature evaluating the efficacy in radicular pain. we present the first three cases of radicular pain successfully treated with a topical formulation of diclofenac, ibuprofe...

Epidemiological studies support a link between cumulative sun exposure and cutaneous squamous cell carcinoma (SCC) development. However, the presumed effects of extended ultraviolet light B (UVB) exposure on tumorigenesis in the sexes have not been formally investigated. We examined differences in ultimate tumorigenesis at 25 weeks in mice exposed to UVB for either 10 or 25 weeks. Additionally,...

The problem of poor bioavailability and clinical efficacy of curcumin can be sorted out after converting crystalline Curcumin (CrysCur) into amorphous NanoCurcumin (NanoCur). Amorphous NanoCur was prepared by converting into nanoemulsion (o/w) using water titration method. The formulation were pre-screen by different physical stress tests, followed by in vitro release study, zeta potential, vis...

Ultraviolet B (UVB) light is the major environmental carcinogen contributing to non-melanoma skin cancer (NMSC) development. There are over 3.5 million NMSC diagnoses in two million patients annually, with men having a 3-fold greater incidence of squamous cell carcinoma (SCC) compared with women. Chronic inflammation has been linked to tumorigenesis, with a key role for the cyclooxygenase-2 (CO...

purpose: to evaluate the analgesic effect of topical sodium diclofenac 0.1% during pan-retinal photocoagulation (prp) in patients with proliferative diabetic retinopathy (pdr). methods: two-hundred informed patients (102 male, 98 female) with pdr were enrolled in this randomized controlled double-masked clinical trial. the treatment group received sodium diclofenac 0.1% eye drops and controls r...

The chromatography of five co-administered drugs i.e. paracetamol, ibuprofen, diclofenac sodium, aspirin and ascorbic acid was performed on various reversed phase layers. The surfactant mediated solvent systems were used with various impregnated silica gel H layers for the chromatography of these five drugs. The various experimental conditions were optimized for the selection of optimum concent...

BACKGROUND AND AIMS Elimination of allergens/topical medications causing contact dermatitis in venous eczema, which poses a significant problem in its chronicity and treatment, provides the basis for better therapeutic outcome. Our objective was to determine the pattern of contact sensitization in venous eczema patients in Himachal Pradesh (India). METHODS Thirty-four patients (M:F, 31:3) and...

PURPOSE To evaluate the analgesic effect of topical sodium diclofenac 0.1% before retinal laser photocoagulation for diabetic retinopathy. METHODS Diabetic patients who were candidates for peripheral laser photocoagulation were included in a randomized, placebo-controlled, intraindividual, two-period, and crossover clinical trial. At the first session and based on randomization, one eye recei...