To assess the frequency of malignancy-associated 30-bp deletion variants of the latent membrane protein 1 (LMP-1) in benign conditions, a comparative sequence analysis was done using samples from 20 American children with acute infectious mononucleosis and 16 Swiss children with chronic tonsillar hyperplasia. The 30-bp deletion variant (LMP-1-del) was present in 66% of patients (12/20 with infe...

Epstein-Barr virus (EBV) persists for life in the infected host. Little is known about EBV reactivation and regulation of virus persistence in healthy individuals. We examined tonsils of chronic tonsillitis patients to detect EBV transcripts, EBV genomes and lytic proteins. LMP1 transcripts were observed in 11 of 15 specimens and BZLF1 transcripts were detected in six. Multiple copies of EBV ge...

BACKGROUND The purpose of this study was to determine prospectively both human papillomavirus (HPV) load and physical status in different types of head and neck squamous cell carcinoma (HNSCC). METHODS HPV DNA, E6/E7 mRNA expression, viral load, and physical status of 184 patients with HNSCC were examined simultaneously by polymerase chain reaction (PCR)-based methods. RESULTS The HPV genom...

COMMUNICATIONSTO THE EDITOR 901 dosis to activity and generalization of the disease seems distinct. Positive tonsillar specimens were fewer than had been reported, but even lower figures have been quoted. These differences might be due to differences in selecting patients, and taking and processing biopsies. In tonsillar specimens, granulomas were sparsely located. Therefore, in some of our cas...

Gonorrhoea of the oral cavity has been demonstrated with increasing frequency in recent years among heterosexuals as well as homosexuals (Schmidt, Hjorting-flansen, and Philipsen, 1961; Cowan, 1969; Bro-Jorgensen and Jensen, 1971; Hellgren, 1971; Owen and Hill, 1972; Ratnatunga, 1972; Rodin, Monteiro and Scrimgeour, 1972; Odegaard and Gundersen, 1973; Wiesner, Tronca, Bonin, Pedersen, and Holme...

Tonsillar cancer incidence has been increasing in Sweden and many other western countries in the last decades despite that other head and neck cancers are decreasing. It is now established that Human Papillomavirus (HPV) can be accredited part of that increase. The aims of this thesis were to investigate any change in incidence of base of tongue cancer, any further increase of tonsillar cancer ...