نتایج جستجو برای: toll like

تعداد نتایج: 658351  

Journal: Iranian Journal of Basic Medical Sciences 2017
Babak Sabermarouf, Behzad Baradaran, Javad Mahmoudi, Leila Sadat-Hatamnezhad Siamak Sandoghchian Shotorbani,

Objective(s): High Mobility Group Box1 (HMGB1) is a nonhistone, DNA-binding protein that serves a crucial role in regulating gene transcription and is involved in a variety of proinflammatory, extracellular activities. The aim of this study was to explore whether HMGB1 stimulation can up-regulate the expression of Toll-like Receptor 2 (TLR2) and Toll-like Receptor 4 (TLR4) on macrophages from p...

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haleh vaez department of pharmacology, faculty of pharmacy, tabriz university of medical sciences, tabriz, iran and student research committee, tabriz university of medical sciences, tabriz, iran moslem najafi department of pharmacology, faculty of pharmacy, tabriz university of medical sciences, tabriz, iran negisa seyed toutounchi student research committee, tabriz university of medical sciences, tabriz, iran jaleh barar research center for pharmaceutical nanotechnology, tabriz university of medical sciences, tabriz, iran abolfazl barzegari research center for pharmaceutical nanotechnology, tabriz university of medical sciences, tabriz, iran alireza garjani department of pharmacology, faculty of pharmacy, tabriz university of medical sciences, tabriz, iran

signaling amp-activated protein kinase (ampk), an energy sensing enzyme, has been implicated in controlling inflammation. in this study we investigated whether activation of ampk by metformin could protect the lung from lipopolysaccharide (lps)-induced acute injury by inhibitingng tlr4 pathway. male wistar rats were randomly divided into 3 groups (n=6): control group received normal saline (0.5...

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