Persistent ischemia in musculocutaneous tissue may lead to wound breakdown and necrosis. The objective of this experimental study was to analyze, whether the gastric peptide ghrelin prevents musculocutaneous tissue from necrosis and to elucidate underlying mechanisms. Thirty-two C57BL/6 mice equipped with a dorsal skinfold chamber containing ischemic musculocutaneous tissue were allocated to fo...

in this study, cadmium (cd) accumulation was studied in an experimental aquatic exposure. mosquitofish (gambusia affinis) were acutely exposed for 96 h to a high concentration of cd (12 mg/l) and were chronically exposed to a low concentration of cd(0.4 mg/l) for 30 days. cd accumulation profiles differed between the two cd exposures. the cd concentation in g. affinis tissues increased linearly...

background one of the main challenges in skin flap surgery is tissue ischemia and following necrosis. the present study compares the effects of fibroblast growth factors 1 and 2 on increasing cutaneous vasculature, improving ischemia, and preventing distal necrosis in ischemic skin flaps in rat model. methods thirty rats were allocated into 3 groups (n=10) and 2×8 cm dorsal random-pattern skin ...

This study pertains to the transition between selective neuronal necrosis and the development of cerebral infarction (pan-necrosis). We infused the neuron selective excitotoxin N-methyl-D-aspartate (NMDA) at a relatively high concentration (10 microliters of 50 mM NMDA in phosphate buffer, pH 7.4) into the rat cortex. Local injection of lactic acid and a minor stab wound in the cortex were used...

Clarias gariepinus is one of the freshwater fish that easy to culture, but also susceptible Edwardsiella tarda infection. Although this convenient treated, consequences bacterial infection are quite detrimental. The method used in study a biochemical test followed by histopathological examination observe tissue changes occur organ. results showed 5 out 17 samples were infected with pathological...

BACKGROUND/AIMS Renalase, a novel flavoprotein expressed in the kidney and heart, reduces renal tubular necrosis and apoptosis, which suggests that it might protect against necrosis and/or apoptosis in myocardial ischemia reperfusion injury (MIRI). The present study thus explored the effects of renalase on Sprague-Dawley (SD) rats subjected to MIRI. METHODS We used Lentivirus-mediated RNA int...

The problem of community-acquired pneumonia in children remains relevant at the present time. Complicated forms, which include pleural empyema, abscess, necrotizing pneumonia, bronchopleural fistulas and acute respiratory distress syndrome do not decrease, despite modern antibacterial therapy availability vaccination against pneumococcus. main pathogens associated with lung destruction are S. p...

Volcanic ash of Mount Sinabung enters the Lau Borus River. One biota in river that is affected by volcanic Mahseer fish. This study aims to determine LC50 from exposure fish, water quality, and tissue histology The concentrations for toxicity tests were 0 mg/L, 66,000 87,000 115,000 152,000 mg/L. results probit analysis showed values at time 24, 48, 72, 96 hours 135,249 106,741 72,210 68,798 re...