A genetic algorithm model has been developed to determine the optimal parameters of mechanical aspects of a silk wire-rope scaffold with the highest predictive accuracy and generalized ability simultaneously. The study pioneered on employing a genetic algorithm (GA) to optimize the parameters of scaffold in tendon and ligament tissue engineering. Experimental results show that the GA model perf...

objective: biomaterial technology, when combined with emerging human induced pluripotent stem cell (hipsc) technology, provides a promising strategy for patient-specific tissue engineering. in this study, we have evaluated the physical effects of collagen scaffolds fabricated at various freezing temperatures on the behavior of hipsc-derived neural progenitors (hipsc-nps). in addition, the coati...

BACKGROUND Tissue organization during embryonic development and wound healing depends on the ability of cells on the one hand to exchange adhesive bonds during active rearrangement and on the other to become fixed in place as tissue homeostasis is reached. Cells achieve these contradictory tasks by regulating either cell-cell adhesive bonds, mediated by cadherins, or cell-extracellular matrix (...

Doctor of Philosophy Mechanical load is believed to play a critical role in tissue formation, growth, maintenance, and disease in vertebrate animals. Although many studies have investigated the effect of mechanical stimuli on biological processes, the dynamics of these processes have not been closely explored. Live long-term observation of the collective behavior of Primary Human Corneal Fibrob...

Background: Autoregulation of blood flow is a marvelous phenomenon balanc- ing blood supply and tissue demand. Although many chemically-based explanations for this phenomenon have been proposed and some of them are commonly used today, biomechanical aspects of this phenomenon was neglected. The biomechanical aspect provides insights to us to model vessel diameter changes more precisely and comp...

the phase transformation phenomenon due to the crystallographic change of shape memory alloys subjected to mechanical or thermal loading is very complicated. regarding the thermo-mechanical coupling effects in shape memory alloys, in case of high  loading rates, heat generation/absorption during the forward/reverse transformation, will lead in temperature-dependent variation and consequently af...

Recently, major achievements in creating decellularized whole tissue scaffolds have drawn considerable attention to decellularization as a promising approach for tissue engineering. Decellularized tissues are expected to have mechanical strength and structure similar to the native tissues from which they are derived. However, numerous studies have shown that mechanical properties change after d...

Quantification of microstructure in conjunction with mechanical testing and modeling may provide new insight into problems of soft tissue mechanics with potential clinical significance. Some general observations concerning this as well as brief discussions of specific examples are presented. Introduction There is an extensive literature on the mechanics of soft tissues. Important results are re...

background: laser-tissue interaction on low-level laser therapy (lllt) has widespread medical applications (e.g., improved wound healing). the tensile strength of radiated tissue by lllt is known to be increased mainly because of cross collagen bands developed after radiation. objective: in this work, we studied the instantaneous effect of radiation of polarized laser beam on the viscoelastic t...

Poly (glycerol sebacate) (PGS) is a promising elastomer for use in soft tissue engineering. However, it is difficult to achieve with PGS a satisfactory balance of mechanical compliance and degradation rate that meet the requirements of soft tissue engineering. In this work, we have synthesised a new PGS nanocomposite system filled with halloysite nanotubes, and mechanical properties, as well as...