t Topics in Membranes, Volume 58 1063-58 ight 2007, Elsevier Inc. All right reserved. DOI: 10.1016/S1063-5823 II. M echanotransduction III. M echanosensitive Channels in Connective Tissue Cells IV. T he Extracellular Environment of Cells V. F orce Transmission from Matrix to Cytoskeleton A. F ocal Adhesions B. S electins VI. E xperimental Models of Force Application to Connective Tissue Cells V...

Objective: The aim of this study was to compare the use of Polypropylene mesh (Prolene) and Sepramesh, a coated Polypropylene mesh with a protective layer of Seprafilm on its visceral side, for the repair of abdominal wall defects in horses. We also aimed to quantify the consequent visceral adhesion and tissue inflammatio Design: Experimental study. Animals: Ten horses. Methods: The horses w...

Objective: To investigate effectiveness of oral clarythromycin and tetracycline on the prevention of postoperative adhesions. Materials and Methods: A total of 28 Wistar-albino rats were divided into four groups. Group 1: abdomen was opened and closed, Group 2: a 2 cm linear incision was made on the right uterine horn and closed, Group 3: 15 minutes after the administration of oral clarithromyc...

Peritoneal adhesions are bands of fibrous tissue that join abdominal organs to each other or the abdominal wall. Adhesions develop rapidly after damage to the peritoneum during surgery, infection, trauma, or irradiation. Postoperative adhesion formation occurs in 93% to 100% of patients undergoing laparotomy, leading to complications such as intestinal obstruction and infertility in women. Adhe...

INTRODUCTION Single-stream hydro-jet dissection is increasingly used in various laparoscopic procedures, but its use requires special equipment. We describe a simple method for using an irrigation system for saline-jet tissue dissection as a useful adjunct prior to adhesiolysis. MATERIAL AND METHODS Intraabdominal adhesions prolong laparoscopic procedures, because tissue planes are difficult ...

The protein cross-linking enzyme tissue transglutaminase binds in vitro with high affinity to fibronectin via its 42-kD gelatin-binding domain. Here we report that cell surface transglutaminase mediates adhesion and spreading of cells on the 42-kD fibronectin fragment, which lacks integrin-binding motifs. Overexpression of tissue transglutaminase increases its amount on the cell surface, enhanc...

Cells perceive information about the biochemical and biophysical properties of their tissue microenvironment through integrin-mediated cell-matrix adhesions, which connect the cytoskeleton with the extracellular matrix and thereby allow cohesion and long-range mechanical connections within tissues. The formation of cell-matrix adhesions and integrin signalling involves the dynamic recruitment a...

Post-operative adhesions are a critical problem in pelvic and abdominal surgery despite a multitude of studies dedicated to finding modalities to prevent their occurrence. Ghrelin administration promotes an anti-fibrotic response in a surgical mouse model of adhesion-induction, but the mechanisms mediating this effect have not been established. In the current study, the molecular mechanisms tha...

In the early stages of breast cancer metastasis, epithelial cells penetrate the basement membrane and invade the surrounding stroma, where they encounter fibroblasts. Paracrine signaling between fibroblasts and epithelial tumor cells contributes to the metastatic cascade, but little is known about the role of adhesive contacts between these two cell types in metastasis. Here we show that MCF-7 ...