نتایج جستجو برای: timps

تعداد نتایج: 955  

Journal: :International journal of oncology 2008
Jean-Luc Brun Annie Cortez Frédéric Commo Serge Uzan Roman Rouzier Emile Daraï

Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play key roles in tumorigenesis, but little is known of their expression according to mucinous or serous type. This study aimed to evaluate the immunohistochemical expression of MMP-2, -7, -9, MT1-MMP, TIMP-1 and -2 in these tumors. A tissue microarray was set up including 99 serous (25 benign, 27 borderline, 47 malignant) and...

Journal: :Circulation 1998
Y Y Li A M Feldman Y Sun C F McTiernan

BACKGROUND Extracellular matrix turnover is regulated by matrix metalloproteinases (MMPs) and a family of tissue inhibitors of metalloproteinases (TIMPs). Together, these proteins may contribute to myocardial remodeling in congestive heart failure. We hypothesized that the expression of MMPs and TIMPs might be differentially regulated in the failing human heart. METHODS AND RESULTS Northern b...

2015
Morio Azuma Alimuddin Tofrizal Rita Maliza Khongorzul Batchuluun Dini Ramadhani Rahimi Syaidah Takehiro Tsukada Ken Fujiwara Motoshi Kikuchi Kotaro Horiguchi Takashi Yashiro

The extracellular matrix (ECM) is important in creating cellular environments in tissues. Recent studies have demonstrated that ECM components are localized in anterior pituitary cells and affect cell activity. Thus, clarifying the mechanism responsible for ECM maintenance would improve understanding of gland function. Tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of...

2012
László Herszényi István Hritz Gábor Lakatos Mária Zsófia Varga Zsolt Tulassay

Matrix metalloproteinases (MMPs) play an important role in the degradation of extracellular matrix components crucial for tumor growth, invasion and metastasis. MMPs are controlled by natural inhibitors called tissue inhibitors of metalloproteinases (TIMPs). We and others have demonstrated that MMPs and TIMPs are especially important in the process of tumor invasion, progression and the metasta...

Journal: :American journal of respiratory cell and molecular biology 2003
Caroline A Owen Zhuma Hu Brooke Barrick Steven D Shapiro

Matrix metalloproteinase (MMP)-9 secreted by activated polymorphonuclear neutrophils (PMN) may play roles in mediating lung injury by degrading extracellular matrix proteins. However, the mechanisms by which MMP-9 retains activity in the presence of tissue inhibitors of metalloproteinases (TIMPs) are not known. We show that MMP-9 is also expressed on the cell surface of PMN, and proinflammatory...

Journal: :Journal of periodontal research 2009
M M Bildt M Bloemen A M Kuijpers-Jagtman J W Von den Hoff

BACKGROUND AND OBJECTIVE Orthodontic tooth movement requires remodeling of the periodontal tissues. The matrix metalloproteinases (MMPs) degrade the extracellular matrix components of the periodontal ligament, while the tissue inhibitors of metalloproteinases (TIMPs) control their activity. Synthetic MMP inhibitors have been developed to inhibit MMP activity. In this study, periodontal ligament...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2006
Salman Choudhary Catherine L Higgins Iou Yih Chen Michael Reardon Gerald Lawrie G Wesley Vick Christof Karmonik David P Via Joel D Morrisett

BACKGROUND Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) play a central role in arterial wall remodeling, affecting stability of fibrous caps covering atherosclerotic plaques. The objective of this study was to determine the spatial distribution of TIMP mass and MMP mass and activity of carotid endarterectomy (CEA) tissues and relate it to the distribution of atherosclerotic les...

Journal: :The Biochemical journal 2008
Magdalini Rapti Susan J Atkinson Meng-Huee Lee Andrew Trim Marcia Moss Gillian Murphy

ADAM (a disintegrin and metalloproteinase) 10 is a key member of the ADAM family of disintegrin and metalloproteinases which process membrane-associated proteins to soluble forms in a process known as 'shedding'. Among the major targets of ADAM10 are Notch, EphrinA2 and CD44. In many cell-based studies of shedding, the activity of ADAM10 appears to overlap with that of ADAM17, which has a simil...

Journal: :Folia histochemica et cytobiologica 2012
Magdalena Groblewska Maria Siewko Barbara Mroczko Maciej Szmitkowski

Esophageal cancer (EC) is one of the most aggressive malignant tumors of the gastrointestinal tract. There are two distinct histological types of EC: esophageal squamous cell carcinoma and adenocarcinoma of the esophagus. Etiologic factors and the patterns of incidence of both subtypes are different. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play an important role in ...

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