Cyclosporin A (CsA)-induced hyperkalemia is caused by alterations in transepithelial K+ secretion resulting from the inhibition of renal tubular Na+, K+ -ATPase activity. Thyroxine enhances renal cortical Na+, K+ -ATPase activity. This study investigated the effect of thyroxine on CsA-induced hyperkalemia. Sprague-Dawley rats were treated with either CsA, thyroxine, CsA and thyroxine, or olive-...

To establish their role in monitoring patients receiving thyroxine replacement biochemical tests of thyroid function were performed in 148 hypothyroid patients studied prospectively. Measurements of serum concentrations of total thyroxine, analogue free thyroxine, total triiodothyronine, analogue free triiodothyronine, and thyroid stimulating hormone, made with a sensitive immunoradiometric ass...

• It has been demonstrated that thyroid hormone and its analogues reduce plasma cholesterol levels both in hypoand in euthyroid individuals; and also that D-thyroxine is much less toxic and less calorigenic than L-thyroxine. Katz and Pick reported that thyroid hormone given to chicks on an atherogenic diet, either as desiccated thyroid or thyroxine, suppressed hypercholesterolemia, but the effe...

In the present investigation the existence of "free" thyroxine in human serum was repeatedly verified by dialysis through cellophane, with paper chromatographic identification of thyroxine in the dialysate. Methods were developed for measurement of the minute amount of thyroxine present in the dialysate that was considered to represent the unbound or diffusible fraction of the hormone in serum....

Factitious hyperthyroidism is a well documented clinical entity where the signs and symptoms of hyperthyroidism are self-induced by the chronic ingestion of excessive amounts of thyroxine l 2. The acute ingestion of large amounts of thyroxine might be thought to carry a risk of acute thyrotoxicosis, but despite high plasma levels of thyroxine this may not be so. Previous reports suggest that su...

Preterm birth is the most common reason for perinatal morbidity and mortality in the western world. It has been shown that in euthyreotic pregnant women with thyroid autoimmune antibodies, L-Thyroxine replacement reduces preterm delivery rate in singleton pregnancies. We investigated in a nonrandomized retrospective observational study whether L-Thyroxine replacement, maintaining maternal free ...

To further evaluate thyroid function in patients with liver disease, we have measured total and free T3 and T4, thyroxine binding globulin, basal and thyrotropin releasing hormone-stimulated thyrotropin and thyroglobulin antibodies in 33 patients with liver cirrhosis, in 22 with chronic hepatitis and in 30 healthy controls. All the patients but one were clinically euthyroid. T3, FT3, T3/thyroxi...

JAMES A. ROBERTS,l.2* M. BERNICE KAACK,1'2 GARY BASKIN,2 AND STEFAN B. SVENSON3 Department of Urology, Tulane University School ofMedicine, New Orleans, Louisiana 701121 Departments of Urology and Pathology, Tulane Regional Primate Research Center, 18703 Three Rivers Road, Covington, Louisiana 70433,2* and Department of Vaccine Research, National Bacteriological Laboratory, and Karolinska Insti...

These observations were made in an effort to determine the rate of production of thyroxine in normal man. Boothby, Sandiford, Sandiford and Slosse (1925) have shown that when thyroxine is injected intravenously at intervals of from two to fourteen days, the average daily dose required to maintain the basal metabolism of a " thyroidless " individual at the normal level is 0.25 mgm. Since the inj...