The flexibility of MAPK cascade responses enables regulation of a vast array of cell fate decisions, but elucidating the mechanisms underlying this plasticity is difficult in endogenous signaling networks. We constructed insulated mammalian MAPK cascades in yeast to explore how intrinsic and extrinsic perturbations affect the flexibility of these synthetic signaling modules. Contrary to biphasi...

a b s t r a c t there are three types of nerve fibers that are involved in the transmission of pain stimuli: c fibers (slower fibers) for thermal, mechanical and chemical stimuli, a-delta fibers for thermal or mechanical stimuli and a-beta fibers for touch stimuli. clinically, this is crucial in making an accurate assessment of the pain level experienced by a suffering patient, in indicating th...

As odor concentration increases, primary olfactory network representations expand in spatial distribution, temporal complexity and duration. However, the direct relationship between concentration dependent odor representations and the psychophysical thresholds of detection and discrimination is poorly understood. This relationship is absolutely critical as thresholds signify transition points w...

Fast reduction of blood water volume due to ultra-filtration via hemodialysis machine and critical threshold of blood water volume can result in clinical complications such as hypotension. When blood water volume reduces during hemodialysis process, the concentration of blood forming elements will increase. One of the methods for the monitoring of the concentration changes is ultrasonic speed m...

Human serum albumin has been used as a model protein for protein folding and ligand binding studies over many decades. Due to its long life period and high concentration in plasma, HSA is highly sensitive to glycation. It is reported that 175 mg/dL glucose concentration is a threshold of kidney activity for the beginning of excretion of glucose. pH denaturation of HSA in absence and presence of...

a greenhouse research work was conducted to study the patterns of na+ and k+ distribution in root, stem and leaf during three growth stages of four iranian alfalfa ecotypes and to find correlation between these patterns and plant salt tolerance. treatments were replicated three times in a factorial experiment of a completely randomized block design. based on the threshold of salt tolerance in a...

The attraction-limited cluster-cluster aggregation of two-dimensional Ising dipolar particles with or without particle-size dispersity is studied. The fast decrease of the number of even-sized clusters for relatively smaller clusters is observed. The threshold concentration is also determined, under which the dynamics of aggregation is explained using the well-known dynamic scaling theory of Vi...