Coronaviruses are the causative agents of respiratory disease in humans and animals, including severe acute respiratory syndrome. Fusion of coronaviruses is generally thought to occur at neutral pH, although there is also evidence for a role of acidic endosomes during entry of a variety of coronaviruses. Therefore, the molecular basis of coronavirus fusion during entry into host cells remains i...

0

482 August 2013 AA science of laws of physics— the motion of gases, of constrict and expand. Theories of heat and pressure, dilate and contract. A stitch of needles and threads, often in acid excess. Volumes of breath, more or less. Power of flows, highs or lows. Choice of dextro and levo, same yet de novo. A science of alpha and beta, support or oppose. A medley of surge and collapse. An art o...

PURPOSE The aims of the study were to analyze the psychometric properties of the Spanish version of the Thought-Action Fusion Questionnaire (TAF-SP), as well as to determine its validity by evaluating the relationship of the TAF-SP to different instruments. PATIENTS AND METHODS TWO GROUPS WERE STUDIED: one comprising 146 patients with eating disorders; and another a group of 200 students. R...

To survive in a world where knowledge is limited, time is pressing, and deep thought is often an unattainable luxury, decision-makers must use bounded rationality. In this precis of Simple heuristics that make us smart, we explore fast and frugal heuristics—simple rules for making decisions with realistic mental resources. These heuristics enable smart choices to be made quickly and with a mini...

*TOM MCMULLEN is a Vice President and North American Reward Practice Leader for Hay Group, accountable for client project delivery, reward capability development and thought leadership. MEL STARK is a Vice President with Hay Group. He is a Regional Reward Practice in the firm's Metro New York Office and manages the firm's relationship with Fortune Magazine. He is focused on adding clarity to cl...

Mitochondrial fusion is thought to be important for supporting cardiac contractility, but is hardly detectable in cultured cardiomyocytes and is difficult to directly evaluate in the heart. We overcame this obstacle through in vivo adenoviral transduction with matrix-targeted photoactivatable GFP and confocal microscopy. Imaging in whole rat hearts indicated mitochondrial network formation and ...

Dynamin-like GTPases of the atlastin family are thought to mediate homotypic endoplasmic reticulum (ER) membrane fusion; however, the underlying mechanism remains largely unclear. Here, we developed a simple and quantitative in vitro assay using isolated yeast microsomes for measuring yeast atlastin Sey1p-dependent ER fusion. Using this assay, we found that the ER SNAREs Sec22p and Sec20p were ...

fusion is a developmental anomaly defined as the :union: of two normally separated tooth buds or the partial splitting of one tooth bud into two buds. depending on the stage of development, fusion may be either complete or incomplete. the significance of this particular case was that this fusion occurred in a posterior permanent mandibular tooth, while such a manifestation is more reported in m...