On two previous occasions, in 19301 and in 1941,2 I have had the honour of reading papers before the Bristol Medico-Chirurgical Society on the surgery of thyrotoxicosis. By that time, operation had become the routine treatment, except in quite mild or very severe cases, and a certain number of children or young women with primary thyrotoxicosis. In 1943, however, thiouracil was introduced by As...

The development of the electrophoretic procedure has led a number of in%-estigators to study the distribution of rat plasma proteins by this method. Rat serum or plasma does not yield the distinct pat,terns that are obtained with human plasma. Moore, Levin, and Leathem (1) could not observe the cr-globulin fraction in normal rat serum dialyzed against phosphate buffer at pH 7.4. After hypophyse...

The administration of thiouracil induced a rise and administration of thyroid substance a decrease of the plasma cholesterol concentration in rats. The concentration and daily output of bile cholesterol was markedly reduced in hypothyroid rats and markedly increased in hyperthyroid rats. Evidence is presented which suggests that the rate of synthesis of cholesterol is significantly increased in...