The cultivated strawberry ( Fragaria × ananassa ) is an economically important fruit crop that intensively bred for improved sensory qualities. diversity of flavors and aromas in results mainly from the interactions sugars, acids, volatile organic compounds (VOCs) are derived diverse biochemical pathways influenced by expression many genes. This study integrates multiomic analyses to identify Q...

Abstract Background Pregnant women with Inflammatory Bowel Disease (IBD) continue thiopurines to maintain remission. Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disorder pregnancy, often causing distressing maternal symptoms and potential implications for outcome. Case studies have reported treatment-resistant intrahepatic in thiopurine-exposed IBD pregnancies. We aimed...

Combination treatment with low-dose thiopurine and allopurinol (AP) has successfully been used in patients with inflammatory bowel disease with a so called skewed thiopurine metabolite profile. In red blood cells in vivo, it reduces the concentration of methylated metabolites and increases the concentration of the phosphorylated ones, which is associated with improved therapeutic efficacy. This...

Current guidelines support the use of corticosteroids and azathioprine as one possible treatment strategy for idiopathic pulmonary fibrosis (IPF). However, some patients with genetic polymorphisms of thiopurine methyltransferase (TPMT) are at risk of severe azathioprine myelotoxicity. The current authors present the case of an 85-yr-old Caucasian male with IPF who developed diffuse alveolar hae...

Most medications exhibit wide interpatient variability in their efficacy and toxicity. For many medications, these interindividual differences result in part from polymorphisms in genes encoding drug-metabolizing enzymes, drug transporters, and/or drug targets (eg, receptors, enzymes). Pharmacogenomics is a burgeoning field aimed at elucidating the genetic basis of differences in drug efficacy ...

amounts of methyl incorporation. Other nucleoside triphosphates besides adenosine triphosphate were capable of sup]x>rting the incorjioration of methyl groups from L-methionine into sRNA. The nonspecificity of the nucleoside triphosphate reaction was shown to be due to an adenosine diphosphokinase reaction and not to nucleoside tri phosphate: L-methionine nucleosidyl transferase activity. Mouse...

amounts of methyl incorporation. Other nucleoside triphosphates besides adenosine triphosphate were capable of sup]x>rting the incorjioration of methyl groups from L-methionine into sRNA. The nonspecificity of the nucleoside triphosphate reaction was shown to be due to an adenosine diphosphokinase reaction and not to nucleoside tri phosphate: L-methionine nucleosidyl transferase activity. Mouse...