نتایج جستجو برای: thioguanine
تعداد نتایج: 1272 فیلتر نتایج به سال:
Thiopurine antimetabolites have been in clinical use for more than 40 years, yet the metabolism of thiopurines remains only partially understood. Data from our previous pediatric phase 1 trial of continuous i.v. infusion of thioguanine (CIVI-TG) suggested that TG was eliminated by saturable mechanism, with conversion of the drug to an unknown metabolite. In this study we have identified this me...
Figure 1 shows the survival of all patients treated in two consecutive periods at the HSC. Before 1972 patients received a variety of drugs; between 1972 and 1975 daunorubicin and cytosine arabinoside (araC) were used in induction, CNS prophylaxis was given with intrathecal chemotherapy and treatment continued . with 6-mercaptopurine or thioguanine for 2 years. There was no improvement in media...
Thiopurines are often the mainstay of treatment for many patients with inflammatory bowel disease. As such, a general understanding of the evidence behind their use and of their metabolism is extremely useful in clinical practice. This review gives a practical overview of thiopurine metabolism, the importance of thiopurine S-methyltransferase testing prior to the start of therapy and the monito...
Lesions of hepatic veno-occlusive disease were found in the needle biopsy specimen of one patient suffering from chronic granulocytic leukaemia and in the liver at necropsy of a second patient suffering from acute myeloid leukaemia. The treatment included administration of 6-thioguanine which was the only relevant compound used in the first patient and which was combined with cytosine arabinosi...
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