Oxidative stress is one of the common problems seen in a variety diseases. Chalcones and particular heteroaryl chalcones had reported with promising antioxidant activities. Hence, present work, we activity twenty thiazole ring bearing chalcone derivatives (1-20). Among tested compounds, compounds 17, 19 20 containing 2-pyridinyl, 3-pyridinyl 2-thiazolyl scaffolds showed superior than standard t...

2-(6,8-Dibromo-2-methylquinazolin-4-yloxy)-acetohydrazide (4) was prepared by the reaction of 6,8-dibromo-2-methylbenzo-[d][1,3]oxazin-4-one with formamide to afford quinazolinone 2, followed by alkylation with ethyl chloroacetate to give the ester 3. Treatment of ester 3 with hydrazine hydrate and benzaldehyde afforded 4 and styryl quinazoline 5. The hydrazide was reacted with triethyl orthofo...

Cancer is the second leading cause of death worldwide. There always a huge demand for novel anticancer. New series pyrazole, pyridine, thiazole derivatives containing sulfonamide moiety were prepared and screened their antitumor activity against breast cancer cell line (MCF-7). The results this investigation revealed that compounds 3 8 had significant anticancer MCF-7 with IC50 values 19.2 14.2...

 The synthesis in water of new sulfone derivatives under microwave irradiation is described. This eco-friendly process leads to the expected products in good yields by reaction of various substituted sulfinates (commercially available or obtained by reduction of the corresponding sulfonyl chlorides) with 4-chloromethyl-2-methyl-5-nitro-1,3-thiazole. In order to evaluate the antiproliferative ef...

Activity of 2-alkylthio-6-aminobenzothiazoles and their 6-A/-substituted derivatives (3-(2-alkylthio6-benzothiazolylaminomethyl)-2-benzothiazolinethiones and 3-(2-alkylthio-6-benzothiazolylaminomethyl)-6-bromo-2-benzothiazolinones) concerning photosynthesis inhibition in algae Chlorella vulgaris and in spinach chloroplasts has been correlated with lipophilicity and dipóle moments of the effecto...

The potential anticholinesterase characteristics of some thiazole derivatives (2a–2j), including the 5-nitrothiophene moiety, were examined in this work. 1H-NMR, 13C-NMR, and HRMS spectral data used to determine structure compounds. Using a modified Ellman's spectrophotometric approach, each compound was tested for its ability inhibit acetylcholinesterase (AChE) butyrylcholinesterase (BuChE) en...

Quinazolinones are a group of heterocyclic compounds that have important biological activities such as cytotoxicity, anti-bacterial, and anti-fungal effects. Thiazole-containing compounds have also many biological effects including antitumor, antibacterial, anti-inflammatory, and analgesic activities. Due to significant cytotoxic effects of both quinazoline and thiazole derivatives, in this wor...