A simple and practical method has been developed for the regioselective nitrosylation of imidazopyridines via C(sp(2))-H bond functionalization using tert-butyl nitrite under mild reaction conditions in a short time. A library of 3-nitrosoimidazopyridines with broad functionalities was synthesized in near quantitative yields. The present protocol is also applicable to imidazo[2,1-b]thiazole and...

An efficient synthesis of 1,3-thiazole drivatives is described via a three component reaction isothiocyanates, tetramethyl thiourea and ethyl bromopyruvate.

A structure-activity relationship (QSAR) analysis of 19 thiazole derivatives with H1-antihistamine activity was carried out. The semi-empirical method AMI was employed to calculate a set of physicochemical parameters for investigated compounds. The principal component analysis (PCA), discriminant function analysis (DFA) and regression analysis (RA) were employed to reduce dimensionality and inv...

The emergence of community-associated methicillin-resistant Staphylococcus aureus (MRSA), including strains resistant to current antibiotics, has contributed to an increase in the number of skin infections reported in humans in recent years. New therapeutic options are needed to counter this public health challenge. The aim of the present study was to examine the potential of thiazole compounds...

2-(Thiophen-2-yl)thiazole was introduced as a π-bridge into diethylamino coumarin and novel coumarin sensitizers were synthesized with cyanoacrylic acid or rhodanine acetic acid as electron acceptor. Their light-harvesting capabilities and photovoltaic performance were investigated and compared with those of a similar sensitizer bearing a phenylthiophene bridge. Replacement of benzene in the π-...

A series of novel thiazole derivatives (A, A1, A2) were synthesized starting from 1-(3-methoxy phenyl) ethanone and thiourea. The compound (A) was obtained by heating 1-(3-methoxy phenyl) ethanone with thiourea in iodine. Compound (A) on treatment with 4-nitrobenzaldehyde afforded (Z)-4-(3-methoxyphenyl)-N-(4-nitrobenzylidene) thiazole-2-amine (A1). Acylation of compound (A) with 4-nitrobenzoyl...

Group 4 metal complexes [M(eta(5)-C(5)Me(4)SiMe(2)-eta(1)-N-2R)(NMe(2))(2)] (R = pyridine, pyrazine, pyrimidine, thiazole, M = Ti; R = pyridine, thiazole; M = Zr) containing the tetramethylcyclopentadienyl-dialkylsilyl bridged amidinato as pendant ligand, were synthesized and characterized by elemental analysis, solution (1)H, (13)C and (15)N NMR spectroscopy and experimental (13)C and (15)N CP...

Isotropic magnetic shielding distributions in the regions of space surrounding oxazole, imidazole, and thiazole are used to investigate aromaticity and bonding in these five-membered heterocycles with two heteroatoms. This is achieved by constructing HF-GIAO and MP2-GIAO (Hartree-Fock and second-order Møller-Plesset perturbation theory with gauge-including atomic orbitals) isotropic shielding p...

A single specimen of Hexabranchus sanguineus, a nudibranch from the Indo-Pacific that is known to sequester kabiramides B and C and other trisoxazole macrolides, yielded new kabiramide analogues, 9-desmethylkbiramide B and 33-methyltetrahydrohalichondramide, and two new unexpected thiazole-containing cyclic peptides in submicromolar amounts. The structures of these cyclic peptides were determin...