The responses of plants to abiotic stress involve the up-regulation of numerous metabolic pathways, including several major routes that engage thiamine diphosphate (TDP)-dependent enzymes. This suggests that the metabolism of thiamine (vitamin B1) and its phosphate esters in plants may be modulated under various stress conditions. In the present study, Zea mays seedlings were used as a model sy...

Submit Manuscript | http://medcraveonline.com Abbreviations: LCPUFAs: Long-Chain Polyunsaturated Fatty Acids; ω6: Omega-6 Family; GLA: γ-Linolenic Acid; AA: Arachidonic Acid; ω3: Omega-3 Family; EPA: Eicosapentaenoic Acid; DHA: Docosahexaenoic Acid; AL: Linoleic Acid; AAL: Alpha-Linolenic Acids; vitamin A: Beta-Carotene; vitamin K: Phylloquinone; vitamin E: Alpha-Tocopherol; B1: Thiamine; B2: R...

Patients with severe Wernicke-Korsakoff syndrome (WKS) associated with vitamin B1 (thiamine) deficiency (TD) show enduring impairment of memory formation. The mechanisms of memory impairment induced by TD remain unknown. Here, we show that hippocampal degeneration is a potential microendophenotype (an endophenotype of brain disease at the cellular and synaptic levels) of WKS in pyrithiamine-ind...

A recent necropsy study has shown that 80% of patients with the Wernicke-Korsakoff syndrome were not diagnosed as such during life. Review of the clinical signs of these cases revealed that only 16% had the classical clinical triad and 19% had no documented clinical signs. The incidence of clinical signs in this and other retrospective pathological studies is very different from that of prospec...

Wernicke's encephalopathy (WE) is a severe neurological syndrome caused by thiamine (vitamin B1) deficiency and clinically characterized by the sudden onset of mental status changes, ocular abnormalities, and ataxia. Apart from chronic alcoholism, the most common cause of WE, a lot of other conditions causing malnutrition and decreasing thiamine absorption such as gastrointestinal surgical proc...

AIMS To assess the effect of mandatory thiamine enrichment of wheat flour on blood thiamine levels in an alcohol-dependent population. METHODS Alcohol-dependent clients (n = 100) entering an inpatient service for the management of alcohol withdrawal had thiamine blood tests and diet interviews. Approximately half (n = 46) the alcohol-dependent participants reported taking vitamin supplements ...

A simplified, simultaneous determination of vitamins B1, B2, B3, and B6 in supplemented infant formulas was developed from a single deproteinized sample extract, with analysis by reversed-phase, ion-pair chromatography with an acidified methanol-water mobile phase. The dioctylsulfosuccinate counter-ion facilitates unique retention of the pyridine-based vitamins (niacinamide and pyridoxine) and ...

Submit Manuscript | http://medcraveonline.com Abbreviations: LCPUFAs: Long-Chain Polyunsaturated Fatty Acids; ω6: Omega-6 Family; GLA: γ-Linolenic Acid; AA: Arachidonic Acid; ω3: Omega-3 Family; EPA: Eicosapentaenoic Acid; DHA: Docosahexaenoic Acid; AL: Linoleic Acid; AAL: Alpha-Linolenic Acids; vitamin A: Beta-Carotene; vitamin K: Phylloquinone; vitamin E: Alpha-Tocopherol; B1: Thiamine; B2: R...

Wernicke's encephalopathy occurs due to thiamine (vitamin B1) deficiency which is characterized by occulomotor dysfunction, confusion and ataxia. Although it is most common with alcoholism, can also be seen due to hyperemesis caused by chemotherapy, Crohn's disease, gastrointestinal system surgery, AIDS, bariatric surgery and longterm feeding with parenteral nutrition. In this case, a 51-year-o...

Thymine-requiring mutants of Escherichia coli were rarely found before the observation by Okada, Yanagisawa, and Ryan (Z. Vererbungslehre 92:403, 1961) that cultures of bacteria grown in the presence of high concentrations of aminopterin, thymine, purines, and serine contain a surprising number of cells unable to synthesize their own supply of thymine. They showed that these thymine-dependent m...