Alcohol use disorder (AUD) has a complex, multifactorial etiology involving dysregulation across several brain regions and peripheral organs. Acute chronic alcohol consumption cause epigenetic modifications in these systems, which underlie changes gene expression subsequently, the emergence of pathophysiological phenotypes associated with AUD. One such mechanism is methylation, can occur on DNA...

Introduction: The use of electrons in the electron therapy to destroy tumoral tissue is dedicated significant contribution of different methods of radiation therapy. Scattered radiation due to exited electrons of the applicator affect the dose out of the field in the patient's normal tissue. The aim of this study is to determine the peripheral dose outside the applicator in the...

background the rate of mother-to-infant hepatitis c virus (hcv) transmission is relatively low, however, this mode of infection is the most important route for childhood hcv involvement. the chances of transmission are increased by the level of maternal hcv viraemia and maternal human immunodeficiency virus (hiv) co infection. objectives the objective of the present study was to determine the p...

land use change is driven by interaction in space and time between humans and the environment that can be captured by computer simulation models (veldkamp and verburg, 2004). in the last few decades, land use change models have played an important role in understanding the causes, mechanisms and consequences of land use dynamics. sleuth is an open source cellular automata based land use change ...

Bone disorders are of significant worry due to their increased prevalence in the median age. Scaffold-based bonetissue engineering holds great promise for the future of osseous defects therapies. Porous composite materials andfunctional coatings for metallic implants have been introduced in next generation of orthopedic medicine for tissueengineering. While osteoconductive materials such as hyd...

A model has been developed to simulate a fixed-exit porous bleed system for supersonic inlets. The fixed-exit model allows the amount of bleed flow to vary according to local flow conditions and fixedexit characteristics of the bleed system. This variation is important for the control of shock-wave/ boundary-layer interactions within the inlet. The model computes the bleed plenum static pressur...