AIMS To determine how the accumulation of drug in mice bearing an extra-hepatic tumor and its therapeutic efficacy are affected by the type of PEGylated liposomal doxorubicin used, treatment modality, and rate of drug release from the liposomes, when combined with radiofrequency (RF) ablation. MATERIALS AND METHODS Two nano-drugs, both long-circulating PEGylated doxorubicin liposomes, were fo...

Liposomes have been employed as drug delivery systems to target solid tumors through exploitation of the enhanced permeability and retention (EPR) effect resulting in significant reductions in systemic toxicity. Nonetheless, insufficient release of encapsulated drug from liposomes has limited their clinical efficacy. Temperature-sensitive liposomes have been engineered to provide site-specific ...

We solve a nonstationary problem of heat conduction for thermosensitive half space in contact with layer under the conditions complex exchange medium constant temperature. To construct solution, we use numerical-analytic approach characterized by application version method successive approximations, linearizing parameters, Laplace integral transformation, and its numerical inversion help Prudni...

PURPOSE To determine in vitro effects of a plasma polymerized N-isopropyl acrylamide (pNIPAM) coating for thermally controllable adhesion to retinal tissue. METHODS Polyimide (50 microm), parylene C [poly(monochloro-p-xylylene)] (20 microm), and poly(dimethyl siloxane) (PDMS) (200 microm) coated with pNIPAM were used as implant materials to test retinal adhesion in enucleated pig eyes. Follow...