We show that the cloud point temperature ( T CP ) of thermoresponsive polyacrylamides is considerably lower in physiologically relevant solvents (phosphate-buffered saline, serum) than pure water. This decrease may be critical for some biomedical applications.

Thermoresponsive polymer segments have been reported to induce lateral microphase separations due their switching transitions from a hydrophilic state hydrophobic one in hydrogels, which result shrinkage and collapse of the networks significantly improved mechanical strength. However, route are assembled into micelles during separations, thermoresponsive toughening mechanisms not fully understo...