The human oesophageal epithelium is subject to damage from thermal stresses and low extracellular pH that can play a role in the cancer progression sequence, thus identifying a physiological model system that can be used to determine how stress responses control carcinogenesis. The classic heat shock protein HSP70 is not induced but rather is down-regulated after thermal injury to squamous epit...

Number of Papers published in peer-reviewed journals: Number of Papers published in non peer-reviewed journals: Final Report: Thermal Analysis for Monitoring Effects of Shock-Induced Physical, Mechanical, and Chemical Changes in Materials Report Title A NETZSCH DSC 404F3 Pegasus® thermal analysis equipment has been acquired for monitoring effects of physical, mechanical and chemical changes, in...

We present a time-dependent cosmic-ray modified shock model for which the calculated Hα emissivity profile agrees well with the Hα flux increase ahead of the Balmer-dominated shock at knot g in Tycho’s supernova remnant, observed by Lee et al. (2007). The backreaction of the cosmic ray component on the thermal component is treated in the two-fluid approximation, and we include thermal particle ...

Plasmid topology varies transiently in hyperthermophilic archaea during thermal stress. As in mesophilic bacteria, DNA linking number (Lk) increases during heat shock and decreases during cold shock. Despite this correspondence, plasmid DNA topology and proteins presumably involved in DNA topological control in each case are different. Plasmid DNA in hyperthermophilic archaea is found in a topo...

The probability that a particle, crossing the shock along a given direction, be reflected backwards along another direction, was shown to be the key element in determining the spectrum of non–thermal particles accelerated via Fermi mechanism around a shock. Here an explicit equation for this probability distribution is given, for both the upstream and downstream sections. Though analytically in...

Heat stress and reduced feed intake negatively affect intestinal integrity and barrier function. Our objective was to compare ileum protein profiles of pigs subjected to 12 hours of HS, thermal neutral ad libitum feed intake, or pair-fed to heat stress feed intake under thermal neutral conditions (pair-fed thermal neutral). 2D-Differential In Gel Electrophoresis and gene expression were perform...

The probability that a particle, crossing the shock along a given direction, be reflected backwards along another direction, was shown to be the key element in determining the spectrum of non–thermal particles accelerated via Fermi mechanism around a shock. Here an explicit equation for this probability distribution is given, for both the upstream and downstream sections. Though analytically in...

Large-scale structure formation, accretion and merging processes, AGN activity produce cosmological gas shocks. The shocks convert a fraction of the energy of gravitationally accelerated flows to internal energy of the gas. Being the main gas-heating agent, cosmological shocks could amplify magnetic fields and accelerate energetic particles via the multi-fluid plasma relaxation processes. We fi...

The current status and needs of thermal biology and physiology as related to clinical hyperthermia are summarized. Emphasis is placed on heat-induced modification of blood flow and microenvironment in tissues, on the biological effects of heat and X-rays, and on the relationship between drug resistance, heat resistance, and thermotolerance in thermochemotherapy. Results from recent studies inve...