Burns are considered one of the most common and shocking forms of trauma. Patients with serious thermal or electrical injury necessitate immediate specialized care to minimize morbidity and mortality. Electrical burns and burn injuries caused by fire, hot liquids, and contact with hot surfaces, have been recognized as a significant and major public health problem in most developing countries. B...

There is as yet no conclusive evidence for the heritability of pain sensitivity in humans. We performed a classical twin study to evaluate the relative contributions of genetic and environmental factors on responses to painful stimuli in women. Ninety-eight pairs of twins, 51 monozygotic (MZ) and 47 dizygotic (DZ), were recruited from the TwinsUK adult registry held at St Thomas' Hospital, Lond...

BACKGROUND Continued improvement in all aspects of the management of thermal injury has resulted in marked improvements in the traditionally reported outcome of mortality. This has resulted in the search for alternative parameters that can be monitored to indicate the performance of burn services. Length of stay (LOS) in hospitalised burn patients has long been considered reflective of injury-a...

INTRODUCTION Burn injury and its subsequent multisystem effects are commonly encountered by acute care practitioners. Resuscitation is the major component of initial burn care and must be managed to restore and preserve remote organ function. Later complications of burn injury are dominated by infection. Burn centers are often called to manage soft tissue problems outside thermal injury includi...

In the heart, thermal injury activates a group of intracellular cysteine proteases known as caspases, which have been suggested to contribute to myocyte inflammation and dyshomeostasis. In this study, Sprague-Dawley rats were given either a third-degree burn over 40% total body surface area plus conventional fluid resuscitation or sham burn injury. Experimental groups included 1) sham burn give...

OBJECTIVE To assess mortality risk and extent of increased length of hospital stay in patients with burn injury with preexisting liver disease. METHODS Records of 31,338 adults who were admitted with burns to 70 burn centers were reviewed from the American Burn Association National Burn Repository. Demographics, percentage burn, and medical characteristics of 180 patients with liver disease w...

Objective: Geriatric patients represent a separate group in the treatment of burn injury regarding pathogenesis, pathophysiology and therapeutic procedure. Methods: From 2000 to 2010 on our burn unit 53 patients aged over 60 years were treated. The mean age of the 27 women and 26 men was 76 years (60 102 years), with an average of 33.2% of total burn surface area. 25 patients (47.2%) had severe...