The importance of studying the pathophysiological bases and clinical correlates of exercise limitation in patients with pulmonary arterial hypertension (PAH) is well established. Two modes of exercise testing, the 6-min walk test (6MWT) and the cardiopulmonary exercise test (CPET), are currently proposed for diagnostic, therapeutic and prognostic finalities. The 6MWT is inexpensive, feasible an...

IT GENERALLY is recognized that prophylactically administered sublingual nitroglycerine exerts a potent yet short-lived beneficial effect on the exercise capacity of patients with coronary artery disease and angina pectoris. Efforts to achieve more prolonged therapeutic action have resulted in the introduction of a variety of nitrate preparations, some with altered molecular structure, others w...

IT GENERALLY is recognized that prophylactically administered sublingual nitroglycerine exerts a potent yet short-lived beneficial effect on the exercise capacity of patients with coronary artery disease and angina pectoris. Efforts to achieve more prolonged therapeutic action have resulted in the introduction of a variety of nitrate preparations, some with altered molecular structure, others w...

IT GENERALLY is recognized that prophylactically administered sublingual nitroglycerine exerts a potent yet short-lived beneficial effect on the exercise capacity of patients with coronary artery disease and angina pectoris. Efforts to achieve more prolonged therapeutic action have resulted in the introduction of a variety of nitrate preparations, some with altered molecular structure, others w...

IT GENERALLY is recognized that prophylactically administered sublingual nitroglycerine exerts a potent yet short-lived beneficial effect on the exercise capacity of patients with coronary artery disease and angina pectoris. Efforts to achieve more prolonged therapeutic action have resulted in the introduction of a variety of nitrate preparations, some with altered molecular structure, others w...

Although many cardiovascular (CVD) medications, such as antithrombotics, statins, and antihypertensives, have been identified to treat atherosclerosis, at most, many of these therapeutic agents only delay its progression. A growing body of evidence suggests physical exercise could be implemented as a non-pharmacologic treatment due to its pro-metabolic, multisystemic, and anti-inflammatory bene...

OBJECTIVES Describe short- and long-term outcomes observed in individuals with hip osteoarthritis (OA) treated with a pre-selected, standardized set of best-evidence manual therapy and therapeutic exercise interventions. METHODS Fifteen consecutive subjects (9 males, 6 females; mean age: 52±7.5 years) with unilateral hip OA received an identical protocol of manual therapy and therapeutic exer...

We live in a time where there is a projected increase in the number of adults surviving to advanced age. With that comes a tremendous financial burden in caring for these elderly individuals, who are likely to develop chronic diseases; both cardiovascular and neurological. Multiple studies have clearly demonstrated the benefits of exercise for preventing cardiovascular disease and age-related c...

IT GENERALLY is recognized that prophylactically administered sublingual nitroglycerine exerts a potent yet short-lived beneficial effect on the exercise capacity of patients with coronary artery disease and angina pectoris. Efforts to achieve more prolonged therapeutic action have resulted in the introduction of a variety of nitrate preparations, some with altered molecular structure, others w...

IT GENERALLY is recognized that prophylactically administered sublingual nitroglycerine exerts a potent yet short-lived beneficial effect on the exercise capacity of patients with coronary artery disease and angina pectoris. Efforts to achieve more prolonged therapeutic action have resulted in the introduction of a variety of nitrate preparations, some with altered molecular structure, others w...