in the present study, we aimed to screen indigenous rhizospheric bacillus strains, capable of producing antiphytopathogenic and plant growth promoting traits. isolate cts-b19 and cts-g24 exhibited quite noticeable antagonistic activity initially against fusarium oxysporum f. sp. ciceri and rhizoctonia bataticola, and, later, against a panel of phytopathogens. partial 16s rrna sequence analysis ...

Increased expression of metalloproteinases is a fundamental aspect of arthritispathology and its control is a major therapeutic objective. In cartilage cultured in the presence of the cytokines interleukin-1 and oncostatin M, chondrocytes produce enhanced levels of metalloproteinases of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) and MMP (matrix metalloproteinase...

Tumor heterogeneity and constant selection of therapy-resistant cancer cells in the tumor require combinatorial approaches to treatment that affect various vital processes tumor. Immunotherapy made a revolution among treatment. Today, many methods are grouped around this type Most antitumor immunotherapeutic agents administered intravenously, which cause serious, often life-threatening, side ef...

Identification of key enzymes regulating melanoma progression and drug resistance has the potential to lead to the development of novel, more effective targeted agents for inhibiting this deadly form of skin cancer. The Akt3, also known as protein kinase B gamma, pathway enzymes regulate diverse cellular processes including proliferation, survival, and invasion thereby promoting the development...

One of the most challenging research areas in pharmacology in the new millennium is to understand why individuals respond differently to drug therapy and to what extent that individual variability in disposition is responsible for the observed differences in therapeutic efficacy and adverse reactions. To answer these complex questions, drug-metabolism research will rely on multidisciplinary app...

Fibrosis, or excessive scarring, is characterized by the emergence of alpha-smooth muscle actin (αSMA)-expressing myofibroblasts and accumulation fibrotic extracellular matrix (ECM). Currently, there a lack effective treatment options for fibrosis, highlighting an unmet need to identify new therapeutic targets. The acquisition phenotype associated with changes in chromatin structure, key determ...