Background. To explore the use of teicoplanin among Chinese patients with Gram-positive infections in a tertiary hospital. Methods. The medical records patients, who were monitored for plasma concentration (TPC) from December 2017 to February 2019, collected. By combining therapeutic drug monitoring (TDM) and nonlinear mixed-effects model, population pharmacokinetic (PPK) model was established....

Background The dosing of vancomycin and gentamicin relies largely on the weight and renal function of a patient. Due to their narrow therapeutic index, these drugs also require therapeutic drug monitoring (TDM) during treatment to ensure efficacy, reduce potential for otoand nephrotoxicity, and reduce potential for resistance. Guidelines for the use of vancomycin and gentamicin, as well as a do...

BACKGROUND Voriconazole is approved for treatment of invasive aspergillosis and other invasive fungal infections, but the role for therapeutic drug monitoring (TDM) is not clear. METHODS We performed a retrospective cohort study of patients at the University of Washington Medical Center and Fred Hutchinson Cancer Research Center from 2007-2009. We compared the effect of therapeutic levels on ...

Background: Therapeutic drug monitoring (TDM) involves the measurement of serum concentrations to optimize pharmacotherapy. Traditionally, blood pressure measurements alone, and not TDM, have been used evaluate antihypertensive response. However, approximately 50% hypertensive patients treated with lifestyle changes drugs fail achieve control. Serum concentration could be useful select optimal ...

Copyright: © 2016 Polo F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. In the clinical practice, therapeutic drug monitoring (TDM) concerns the analytical determination of pharmaceutical drug concent...

High mortality and morbidity rates associated with severe infections in the critically ill continue to be a significant issue for the healthcare system. In view of the diverse and unique pharmacokinetic profile of drugs in this patient population, there is increasing use of therapeutic drug monitoring (TDM) in attempt to optimize the exposure of antibiotics, improve clinical outcome and minimiz...

Efficacy of therapeutic drug monitoring (TDM) of vancomycin (VCM) was retrospectively investigated in 184 patients with methicillin-resistant Staphylococcus aureus (MRSA) infection. The incidence of nephrotoxicity was compared between the patients who received TDM practice (TDM group, n=73) and did not (non-TDM group, n=111). Creatinine clearance (CLcr) values decreased significantly after the ...

Recent advancements in point-of-care (PoC) technologies show great transformative promises for personalized preventative and predictive medicine. However, fields like therapeutic drug monitoring (TDM), that first allowed for personalized treatment of patients' disease, still lag behind in the widespread application of PoC devices for monitoring of patients. Surprisingly, very few applications i...

Introduction: 
 Therapeutic drug monitoring (TDM) measures the level of medications within biological fluids. Valproic acid (VPA) is a narrow therapeutic index anti-epileptic. Measurement its essential for evaluation safety and efficacy. Aim was to evaluate benefit TDM services in patients taking with respect outcome improvement prevention adverse events linked dosage errors,
 Methodo...

Therapeutic drug monitoring (TDM) is one of the most complex laboratory testing processes in modern laboratory medicine practice. Based on the simple engineering principle of feedback control, TDM strives to regulate an individual’s exposure to a drug by measuring the drug’s concentrations, usually at steady state and at distributional equilibrium, and then use these concentrations to determine...