We construct a phase-field model for collective cell migration based on a Ginzburg-Landau free-energy formulation. We model adhesion, surface tension, repulsion, coattraction, and polarization, enabling us to follow the cells' morphologies and the effect of their membranes fluctuations on collective motion. We were able to measure the tissue surface tension as a function of the individual cell ...

The effects of a stretch-release cycle (approximately 25% of the resting muscle fibre length, Lo) on both tension and [Ca2+]i in small, unstimulated, intact muscle fibre bundles isolated from adult and neonatal rats were investigated at 20 degrees C. The results show that the effects of the length change depended on the age of the rats. Thus, the length change produced three effects in the neon...

The tension–tension fatigue behavior was investigated for a hybrid composite rod comprised of a unidirectional carbon fiber core and a glass fiber shell. Fatigue tests were performed at three R-ratios and four maximum applied stress levels (MAS) while recording the secant modulus at each cycle, and acoustic emission (AE) sensors were employed to monitor the activation of fatigue mechanisms. Fat...

Cellular tension has implications in normal biology and pathology. Membrane adhesion receptors serve as conduits for mechanotransduction that lead to cellular responses. Ligand-conjugated magnetic beads are a useful tool in the study of how cells sense and respond to tension. Here we detail methods for their use in applying tension to cells and strategies for analyzing the results. We demonstra...

Incivility remains a major challenge for online discussion platforms, to such an extent that even conversations between well-intentioned users can often derail into uncivil behavior. Traditionally, platforms have relied on moderators to---with or without algorithmic assistance---take corrective actions as removing comments banning users. In this work we propose complementary paradigm directly e...

Human dental pulp stem cells (hDPSCs) are a source for cell therapy. Before implantation, an in vitro expansion step is necessary, with the inconvenience that hDPSCs undergo senescence following a certain number of passages, loosing their stemness properties. Long-term in vitro culture of hDPSCs at 21% (ambient oxygen tension) compared with 3-6% oxygen tension (physiological oxygen tension) cau...