Replication forks are vulnerable to wayward nuclease activities. We report here our discovery of a new member in guarding genome stability at replication forks. We previously isolated a Drosophila mutation, wuho (wh, no progeny), characterized by a severe fertility defect and affecting expression of a protein (WH) in a family of conserved proteins with multiple WD40 repeats. Knockdown of WH by ...

The MUS81-EME1 endonuclease maintains metazoan genomic integrity by cleaving branched DNA structures that arise during the resolution of recombination intermediates. In humans, MUS81 also forms a poorly characterized complex with EME2. Here, we identify and determine the structure of a winged helix (WH) domain from human MUS81, which binds DNA. WH domain mutations greatly reduce binding of the ...

I argue that the interpretation of expressions consisting of disjunction marker and wh-element (wh-DISJ expressions), which varies across languages, constitutes a case of semantic variation. In Hausa, these expressions denote universal generalized quantifiers, which give rise to free choice effects in intensional contexts (Giannakidou 2001). The universal meaning is derived in compositional fas...

This paper presents a new criticism of reductive approaches to knowledge-‘wh’ (i.e., those approaches on which whether one stands in the knowledge-‘wh’ relation to a question is determined by whether one stands in the knowledge-‘that’ relation to some answer(s) to the question). It argues in particular that the truth of a knowledge-‘wh’ attribution like ‘Janna knows where she can buy an Italian...

This paper argues that wh-in situ is interpreted in its original position. Focusing on the ambiguity of how many sentences, it shows that the semantic behavior of wh in-situ can be explained without postulating LF (phrasal) movement. It is then pointed out that the fact that wh-phrases in situ lack anti-reconstruction effects follows directly from this non movement approach. The paper also show...

We study Weyl-Heisenberg (=Gabor) expansions for either L2(IR ) or a subspace of it. These are expansions in terms of the spanning set X = (EM φ : k ∈ K, l ∈ L,φ ∈ Φ), where K and L are some discrete lattices in IR, Φ ⊂ L2(IR ) is finite, E is the translation operator, and M is the modulation operator. Such sets X are known as WH systems. The analysis of the “basis” properties of WH systems (e....

We study Weyl-Heisenberg (=Gabor) expansions for either L 2 (IR d) or a subspace of it. These are expansions in terms of the spanning set where K and L are some discrete lattices in IR d , L 2 (IR d) is nite, E is the translation operator, and M is the modulation operator. Such sets X are known as WH systems. The analysis of the \basis" properties of WH systems (e.g. being a frame or a Riesz ba...

This production study investigates the interaction of prosody, word order and information structure with respect to whconstituents in Urdu. We contrasted immediately preverbal wh-constituents with immediately postverbal ones. The preverbal position is the default focus position in Urdu; the appearance of wh-constituents in the immediately postverbal position within the verbal complex is not wel...

How should one understand knowledge-wh ascriptions? That is, how should one understand claims such as ‘‘I know where the car is parked,’’ which feature an interrogative complement? The received view is that knowledge-wh reduces to knowledge that p, where p happens to be the answer to the question Q denoted by the wh-clause. I will argue that knowledge-wh includes the question—to know-wh is to k...