Introduction: The interaction between steroid hormones and neurotransmitters such as GABA has been proved. The regulation of muscimol binding to high-affinity GABAA receptors by estradiol and progesterone has been studied within distinct brain regions using in vitro quantitative autoradiography. There are few studies about the mechanism of the effect of steroid hormones on behaviors such as ...

Background Epidemiology studies have indicated an association of apolipoprotein E (ApoE) genetic polymorphism and circulating steroid hormone levels with the risk of Alzheimer's disease. The established physiologic relationship between apolipoproteins and steroid hormone indicate an important role of ApoE polymorphism in impacting the relationship between serum steroid hormones and cognition in...

AIM This study was conducted to understand whether serum level of the steroid and metabolic hormones may be indicative of their level in ovarian follicular fluid (FF) in porcine, and its influence on fertility. MATERIALS AND METHODS Ovaries from pigs (n=32) of two genetic groups, namely, native (Ghungroo; n=16) and crossbred (Hampshire × Ghungroo; n=16) were collected. Both the genetic groups...

this study was performed to evaluate the effect of atenolol on the serum concentration of tt4 and tt3 in subclinical hyperthyroid patients. due to the i n s u fficient information about the effect of atenolol on serum level of these hormones, the aim of this research was to shade some light on the subject. fifteen subclinical hyperthyroid patients entered this study. each patient received 100 m...

The effects of steroid hormones, glucagon and insulin on rat liver phosphatidate phosphohydrolase (PAP) activity were studied both in vitro and in vivo. Incubation of rat hepatocytes with each hormone showed that dehydroepiandrosterone (DHEA), progesterone and testosterone increase PAP activity by 44.6, 37 and 36.9%, respectively. Estradiol, however, decreased enzyme activity by 13.6% under...

Oestrogenic steroid hormones (‘oestrogens’) have a crucial role in cellular regulation in all vertebrate species. The levels required to bring about such changes are very low, around 0.1–1 pg/ml (picograms per millilitre) of serum. It has been known for over five decades that oestrogens affect the development of the male reproductive system of mammals (Zuckerman, 1940). Nonetheless, oestrogenic...

The discovery of a plasma membrane ABC protein that exports steroids in yeast highlights the possibility that similar membrane sorting systems in mammalian cells may modulate the access of steroids to their receptors.

preeclampsia is a major cause of morbidity and mortality during pregnancy. several independent investigators have demonstrated the association of androgens with hypertension. the main purpose of this study was to determine whether maternal levels of sex hormones, especially testosterone, are higher in patients with preeclampsia than in matched normotensive control subjects. serum levels of test...