Secukinumab is a human monoclonal antibody with demonstrated efficacy for moderate to severe psoriasis; it binds to and neutralizes interleukin (IL)-17A. The pharmacokinetic (PK) parameters of secukinumab were best described by a 2-compartment model. Only weight was included in the final model, as other covariates did not affect clinical relevance. The estimated serum clearance of secukinumab w...

The equation of state (EOS) of finite nuclei is constructed in the relativistic Thomas-Fermi theory using the non-linear σ − ω − ρ model. The caloric curves are calculated by confining the nuclei in the freeze-out volume taken to be a sphere of size about 4 to 8 times the normal nuclear volume. The results obtained from the relativistic theory are not significantly different from those obtained...

â  abstract: in this work, the kinetics of ethane hydrate formation has been studied experimentally and a kinetic model based on chemical affinity has been described for predicting the hydrate growth process in the stirred batch reactor at a constant volume. the experiments were done with both pure water and aqueous solution of sodium dodecyl sulfate (sds). the effect of sds on formation kineti...

INTRODUCTION Recombinant activated factor VII (rFVIIa) has been used as adjunctive therapy in trauma patients with severe bleeding. However, its pharmacokinetics profile remains unknown. METHODS In two placebo-controlled studies in patients with blunt and penetrating trauma, the pharmacokinetics of rFVIIa given at an initial dose of 200 microg x kg-1 after transfusion of eight red blood cell ...

This study establishes a target motion model and an observation model under the condition of colored noise by using the Kalman filter based on an improved IMM (interactive multiple model) for maneuvering target tracking. To improve the overall performance of IMM algorithm, we proposed to combine the CV (constant velocity) and CA (constant acceleration) models with the "current" statistical mode...