Mathematical modeling is being increasingly recognized within the biomedical sciences as an important tool that can aid the understanding of biological systems. The heavily regulated cell renewal cycle in the colonic crypt provides a good example of how modeling can be used to find out key features of the system kinetics, and help to explain both the breakdown of homeostasis and the initiation ...

Prediction Based on Mean Subset H Ojelund, P J Brown, H Madsen & P Thyregod a Informatics and Mathematical Modelling, The Technical University of Denmark, DK-2800 Lyngby, Denmark b Institute of Mathematics and Statistics, University of Kent at Canterbury, Canterbury, Kent, CT2 7NF, UK c Informatics and Mathematical Modelling, The Technical University of Denmark, DK-2800 Lyngby, Denmark d Inform...

Transcription activator-like effectors (TALEs) are proteins secreted by Xanthomonas bacteria to aid the infection of plant species. TALEs assist infections by binding to specific DNA sequences and activating the expression of host genes. Recent results show that TALE proteins consist of a central repeat domain, which determines the DNA targeting specificity and can be rapidly synthesized de nov...

Keynotes Dr. James Smithies: Building the Canterbury Earthquakes Digital Archive Senior Lecturer in Digital Humanities, University of Canterbury Dr. Ray Hidayat: Interesting Algorithms in Telogis Route Telogis Route is full of complex algorithms. When planning driver territories, how can we estimate the required driving time quickly? When optimising routes, how can we discourage routes from ove...

1 School of Biosciences, University of Kent, Canterbury, CT2 7NJ, United Kingdom and 2 Institut de Biologie Physico-Chimique (Unité Propre de Recherche 9073, Centre National de la Recherche Scientifique), 13 Rue Pierre et Marrie Curie, 75005 Paris, France. Running title: SlyA and type 1 fimbriation Address correspondence to: Ian C. Blomfield, School of Biosciences, University of Kent, Canterbur...

The University of Kent at Canterbury PSSRU Cornwallis Building, University of Kent at Canterbury, Canterbury, Kent CT2 7NF Tel: 01227 823963 Fax: 01227 827038 Email: [email protected] Site Director: Professor Ann Netten The London School of Economics PSSRU London School of Economics, Houghton Street, London WC2 2AE Tel: 020 7955 6238 Fax: 020 7955 6131 Email: [email protected] Site Director: Profe...

We examined the threat status of the low tree Pittosporum patulum throughout its range in eastern South Island, based on plot-based sampling of habitat, defoliation by mammalian herbivores, demographic and dieback characteristics. Using environmental modelling (Land Environments of New Zealand), we found no explanation for the ‘gap’ in its disjunct distribution from Nelson–Marlborough–north Can...

Transcription Activators-Like Effectors (TALEs) belong to a family of virulence proteins from the Xanthomonas genus of bacterial plant pathogens that are translocated into the plant cell. In the nucleus, TALEs act as transcription factors inducing the expression of susceptibility genes. A code for TALE-DNA binding specificity and high-resolution three-dimensional structures of TALE-DNA complexe...

a r t i c l e i n f o Background: Transcription activator-like effectors (TALEs) are effector proteins secreted by certain plant pathogenic bacteria when infecting their hosts. Upon translocation, TALEs bind via a well-deciphered recognition code to specific sequences in the promoter region of targeted host genes, thereby activating expression of those targeted genes. Gene activation induced by...

The deep sedimentary biosphere, extending 100s of meters below the seafloor harbors unexpected diversity of Bacteria, Archaea, and microbial eukaryotes. Far less is known about microbial eukaryotes in subsurface habitats, albeit several studies have indicated that fungi dominate microbial eukaryotic communities and fungal molecular signatures (of both yeasts and filamentous forms) have been det...