BACKGROUND Sickle cell trait (SCT) is the heterozygous form of sickle cell disease and expectedly should be a benign state with no complications ascribed to it. There are numerous reports challenging its being a benign condition, though this is controversial. METHODS AND RESULTS A review of the results of the accompanying investigations done on some of the patients show that beta thalassemia ...

A 23-yr-old man of Greek-Italian ancestry with mild anemia was found to be heterozygousforHbD(Punjab) fi12 glu -‘ gIn and fi-thalassemia. HbA was not detected upon electrophoresis of the subject’s hemolysate, and no synthesis of fiA globin was demonstrated after incubation of peripheral blood or bone marrow with 3H-Ieucine. The thalassemia gene was thus of the fi variety. The fiD/a synthesis ra...

OBJECTIVE Stable mixed chimerism (MC) may result in cure for thalassemia major patients following hematopoietic stem cell transplantation (HSCT), but rejection can occur. Twenty-eight HSCTs for thalassemia major were reviewed retrospectively to evaluate the clinical course of MC with possible risk factors and predictors of outcome, with a median follow-up of 1669 days (811-3576 days). METHODS...

Thalassemia and Sickle Cell Disease (SCD) both are genetic blood disorders occurring by destruction in red blood cells (RBCs). Every year about 300,000 infants worldwide are born with Thalassemia syndrome (30 per cents) and sickle cell anaemia (70 per cents. Globally, the percentage of carriers of Thalassemia is greater than that of carriers of SCA, but because of the high frequency of the sick...

There are an estimated 45 million carriers of β-thalassemia trait and about 12,000-15,000 infants with β-thalassemia major are born every year in India. Thalassemia major constitutes a significant burden on the health care system. The burden of thalassemia major can be decreased by premarital screening and prenatal diagnosis. The success of prenatal diagnosis requires proper knowledge of spectr...

Objective: To determine the frequency of beta thalassemia trait among pregnant women presenting with anemia.
 Method: A cross sectional study was conducted in Gynecology & Obstetric department, district headquarters hospital Mardan from January 2019 to June 2020. This includes all who presented anemia and having age 15 45 years. Patients known hemoglobinopathies were excluded study. Co...

Amelogenesis imperfecta is a group of genetic disorders that affects both the morphology and quality of tooth structure. Although the disease entity is primarily associated with abnormalities of dental and oral structures, it has been reported to be associated with a few syndromes. A 9-year-old girl with minor thalassemia referred to the Department of Pediatric Dentistry of the Mashhad Faculty ...

Amelogenesis imperfecta is a group of genetic disorders that affects both the morphology and quality of tooth structure. Although the disease entity is primarily associated with abnormalities of dental and oral structures, it has been reported to be associated with a few syndromes. A 9-year-old girl with minor thalassemia referred to the Department of Pediatric Dentistry of the Mashhad Faculty ...