This work presents poly(terephthalic-co-glycerol-g-fumaric acid) (TGF) as a novel water-soluble polymeric nano-additive for the modification of polyethersulfone ultrafiltration membrane. The TGF was harnessed pore former, aiming to improve membrane surface porosity and hydrophilicity. Modified membranes were characterized observe influence varying content on their hydrophilicity, porosity, morp...

Background: Laparoscopy induces changes and detachment of mesothelial structure. Studies on the prevention cell are rarely found. The Dayak tribe uses onion (Eleutherine americana L. Merr) as a wound-healing agent due to its anti-inflammatory antioxidant activities. This study aimed prove activities onions in preventing damage after laparoscopy.
 Materials methods: Thirty male Sprague-Dawl...

Objective Adult stem cells which are derived from different tissues, with their unique abilities to self-renew and differentiate into various phenotypes have the potential for cell therapy and tissue engineering. Human adipose tissue is an appropriate source of mesenchymal stem cells with wide differentiation potential for tissue engineering research. In this study isolated stem cells from hum...

Background & Aims: Numerous studies have reported the renoprotective effects of exercise in both human and animal models of diabetic nephropathy. However, detailed mechanism of action by which exercise has a favorable influence on renal fibrogenic factors is not yet fully understood. Therefore, the aim of this study was to assess the effect of swimming exercise on the activity ...

Background: Curcumin, extracted from turmeric, represents enormous potential to serve as an anticancer agent. Telomerase is viewed as a prominent molecular target of curcumin, and transforming growth factor-β1 (TGFβ1) has proven to be a major inhibitory signaling pathway for telomerase activity. In the current study, we aimed to explore suppressive effects of nanocurcumin on telomeras...

  Objective(s):Transforming growth factor-β(TGF-β) is involved in colorectal cancer (CRC). The SD-208 acts as an anti-cancer agent in different malignancies via TGF-β signaling. This work aims to show the effect of manipulation of TGF-β signaling on some miRNAs implicated in CRC. Materials and Methods: We investigated the effects of SD-208 on SW-48, a colon adenocarcinoma cell line. The cell li...

Background: Growth factors play a major part in wound healing in many tissues including the periodontium. Transforming growth factor-β1 (TGF-β1) is one of these factors present in the gingival crevicular fluid. In addition, it is considered as one of the most important anti-inflammatory cytokines. Interleukin-1β is a proinflammatory cytokine that presents itself in gingival inflammation and the...

Background: TGF-β has long been considered as the main inducer of Tregs in tumor microenvironment and is the reason for the aberrant number of Tregs in tumor-bearing individuals. Recently, it has been suggested that the enzyme arginase I is able to mediate the induction of Tregs in a TGF-β-independent fashion. The recombinant WW2/WW3 domains from smad ubiquitination regulatory factor 2 molecule...

​Background and purpose: Glycation products, oxidative stress, and inflammation contribute to the development of diabetic nephropathy (DN) due to the elevation of transforming growth factor-β1 (TGF-β1). This study aimed at investigating the effect of Cysteine (Cys) on TGF-β in DN rat model. Materials and methods: In this experimental study, 40 male Wistar rats were randomly divided into four g...

an appropriate differentiation of distinct human cd4+ t cell subset is critical for manipulating these cells for using in immunity related diseases. despite various attempts to clarify the role of different factors involved in th17 differentiation, many crucial contradictions yet remained to be optimized. although it has been shown that the differentiation of in-vitro th17 cells culture conditi...