To realize the energy recovery of wheat straw, pyrolysis behavior straw was studied at three heating rates (10, 20, and 30 K/min) based on thermogravimetric analysis (TG–DTG). Kinetics thermodynamics were analyzed using Flynn–Wall–Ozawa (FWO) Kissinger–Akahira–Sunose (KAS) model-free methods, reaction mechanism determined Coats–Redfern (CR) model-fitting method. The results show that there are ...

Dolutegravir (DTG) is approved in the United States to treat HIV-1-infected patients weighing ≥30 kg. A dispersible DTG tablet formulation was recently developed for pediatric patients. This study compares the pharmacokinetics (PK) of the dispersible tablet with that of a previously evaluated granule formulation. In this randomized, open-label, crossover study, 15 healthy adults received single...

BACKGROUND Dolutegravir (DTG), a once-daily, human immunodeficiency virus type 1 (HIV-1) integrase inhibitor, was evaluated for distribution and antiviral activity in cerebrospinal fluid (CSF). METHODS ING116070 is an ongoing, single-arm, open-label, multicenter study in antiretroviral therapy-naive, HIV-1-infected adults. Subjects received DTG (50 mg) plus abacavir/lamivudine (600/300 mg) on...

BACKGROUND  The objective of this study was to quantify human immunodeficiency virus (HIV) type 1 RNA decay and dolutegravir (DTG) concentrations in the semen of HIV-infected patients receiving DTG-based first-line therapy. METHODS  This was a prospective, single-arm, open-label study including 15 HIV-1-infected, antiretroviral therapy-naive men starting once-daily treatment with DTG (50 mg) ...

Two new hexahydropyrimidine compounds were prepared in high yield by condensation of an equimolar amount of 1,3-diamine with 2-dipyridylketone at room temperature in dichloromethane. The desired hexahydropyrimidine structures were confirmed on the basis of their UV-Visible, elemental analysis, FT-IR, 1H-NMR, TG/DTG, and EI-MS ...

Phthalimide was reacted with chlorosulfonic acid to give sulfonic acid-functionalized phthalimide (SFP), which characterized by 1H NMR, 13C NMR, FT-IR, XRD (X-ray diffraction), SEM (scanning electron microscopy), EDX (energy-dispersive X-ray), mass, TG (thermogravimetry) and DTG (derivative thermal gravimetry) spectra. Afterward, its catalytic activity was examined for the condensation of aryla...

In Juazeiro de Piauí and Castelo do Piauí, two cities in northeast Brazil, mined morisca rock is widely used civil construction for external coating applications. Aiming at a sustainable practice its extraction, which includes the economical use of tailings from mining, this work presents solution discarded materials processing Piauí. context, an analysis results using as substitute clay applic...

BACKGROUND Recommended human immunodeficiency virus (HIV) treatment regimens in the United States contain 3 antiretroviral agents, costing >$30 000/person/year. Pilot studies are evaluating the efficacy of dual therapy with dolutegravir (DTG) and lamivudine (3TC). We examined the potential cost-effectiveness and budget impact of DTG + 3TC regimens in the United States. METHODS Using a mathema...

Aim of this study to investigate the thermal and morphological behaviour different types biomass feedstock. For investigation we used thermo-gravimetric (TG) analysis derivative (DTG) analysis. The feedstocks were conceded out under vigorous conditions using nitrogen gas at specific heating rates gradient temperature from 25°C 1000°C. results show that decomposition on these feedstocks. First-o...