Since 1984, the Radiological Physics Center (RPC) has used the American Association of Physicists in Medicine Task Group 21 (TG-21) protocol (absorbed dose determination) as the basis of its On-site Dosimetry Review visits to institutions participating in the National Cancer Institute's cooperative clinical trials. Subsequent to the TG-21 protocol, the Task Group 25 (TG-25) report on electron-b...

We introduce TG/MC, a Monte-Carlo approach for evaluating the impact of uncertainty about vulnerabilities upon forecasts of security for a real-world system modeled by a protection graph. A TG/MC model defines a vulnerability as a potential change to an otherwise safe initial protection graph that, if exploited, leads to an unauthorized state, a violation of the system’s security policy through...

TDP-43 is a pathogenic protein: its normal function in binding to UG-rich RNA is related to cystic fibrosis, and inclusion of its C-terminal fragments in brain cells is directly linked to frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Here we report the 1.65 A crystal structure of the C-terminal RRM2 domain of TDP-43 in complex with a single-stranded DNA. We s...

Environmental concerns about fiber composites are leading manufacturers to consider bio-based alternatives petroleum-derived epoxies. Such a substitution is hindered by lack of information, so commercially available epoxy systems have been compared, their mechanical properties measured, and produced vacuum infusion. Most high content resins for infusion use conventional curing agents. Bio-based...

Martherus R, Jain R, Takagi K, Mendsaikhan U, Turdi S, Osinska H, James JF, Kramer K, Purevjav E, Towbin JA. Accelerated cardiac remodeling in desmoplakin transgenic mice in response to endurance exercise is associated with perturbed Wnt/ -catenin signaling. Am J Physiol Heart Circ Physiol 310: H174 –H187, 2016. First published November 6, 2015; doi:10.1152/ajpheart.00295.2015.—Arrhythmogenic v...

In lower vertebrates, retinal ganglion cells (RGCs) can regenerate their axons and reestablish functional connections after optic nerve injury. We show here that in goldfish RGCs, the effects of several trophic factors converge on a purine-sensitive signaling mechanism that controls axonal outgrowth and the expression of multiple growth-associated proteins. In culture, goldfish RGCs regenerate ...

BACKGROUND Propofol when given as 2 mg/kg IV bolus for induction of anesthesia is known to cause hypotension requiring vasopressors. The objective of our study was to compare Propofol 2 mg/kg single IV bolus (Precalculated group, PG) with the titration of Propofol (Titration group, TG) to clinical parameters as 10 mg IV increments every 3 seconds on hemodynamic Parameters and Bispectral Index (...

Induction of cutaneous squamous cell carcinoma (SCC) in mice, by topical chemical [9,10-dimethylbenzanthracene (DMBA) and phorbol 12myristate 13-acetate (PMA)] application, is a multistep process involving papilloma formation and progression to carcinoma. We have generated a transgenic (Tg) mouse [keratin-14 (K14)-survivin] with skin expression of survivin, an inhibitor of apoptosis expressed i...

Induction of cutaneous squamous cell carcinoma (SCC) in mice, by topical chemical [9,10-dimethylbenzanthracene (DMBA) and phorbol 12-myristate 13-acetate (PMA)] application, is a multistep process involving papilloma formation and progression to carcinoma. We have generated a transgenic (Tg) mouse [keratin-14 (K14)-survivin] with skin expression of survivin, an inhibitor of apoptosis expressed ...