نتایج جستجو برای: tetrazole

تعداد نتایج: 701  

Journal: :Bioorganic & medicinal chemistry letters 2008
Aldo Segura-Cabrera Mario A Rodríguez-Pérez

A structure-based virtual screening protocol was used to predict Mycobacterium tuberculosis shikimate kinase (MtSk) inhibitors. Docking simulations were performed using eHiTS software and 644 drug-like compounds were identified as potential inhibitors. Forty-two percent of such inhibitors had a structural relationship to a triazole or a tetrazole heteroaromatic system which may provide a candid...

2013
M. A. KALE M. R. PEHARKAR

A series of tetrazole derivatives (3a-h) were synthesized and screened for antioxidant activity by nitric oxide free radical scavenging activity. All the synthesized compounds were structurally elucidated by spectral techniques such as IR, H NMR spectroscopy and mass spectrometry. The compounds 3b, 3d 3f and 3h exhibited promising antioxidant activities which were found to be comparable with st...

2018
Vijayakumar K Sountharrajan S Suganya E

Anticancer approaches may employ change of molecular structure to enhance preventive influence of chemical agents. The present examination concerned the potential anticancer impact of modified heterocyclic compounds. A strategy was developed to combine tetrazole moieties from different diamines with 2-aminobenzoic and substituted benzoyl chloride compounds with attention to synthesis, character...

2015
Khalil Beyki Reza Haydari Malek Taher Maghsoodlou

Some pentafluoropyridine derivatives have been synthesized by the reaction of pentafluoropyridine with appropriate C, S and N-nucleophile such as malononitrile, 1-methyl-tetrazole-5-thiol and piperazine. These reactions provided 4-substituted 2,3,5,6-tetrafluoropyridine derivatives in good yields. All the compounds were characterized using (1)H, (13)C and (19)F-NMR spectroscopy and X-ray crysta...

2014
S. Mohammad Sajadi Mehdi Maham Mohammad Sajadi

During this study the application of Natrolite zeolite was investigated as a solid acid catalyst for efficient preparation of 5substituted 1H-tetrazole derivatives. Excellent yields of products were obtained with a wide range of substrates. After completion of the reaction, the catalyst was recovered by filtration and reused several times with only a slight decrease of activity observed under t...

Journal: :Organic & biomolecular chemistry 2008
Ramakrishna I Anegundi Vedavati G Puranik Srinivas Hotha

Various 1,2,3-triazole and 1,2,3,4-tetrazole fused multi-cyclic compounds were synthesized from carbohydrate derived azido-alkyne and azido-cyanide substrates. The acid sensitive 1,2-O-isopropylidene group of the furanosyl sugar was utilized for diversification to glycosides and nucleosides under Fischer glycosidation and Vorbruggen's conditions, respectively.

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2004
Norie Momiyama Hiromi Torii Susumu Saito Hisashi Yamamoto

The approach using pyrrolidine enamine as substrate has been studied for this synthesis, and an important catalyst structural feature has been developed. After survey of pyrrolidine-based Brønsted acid catalyst, tetrazole catalyst (3f) was found to be optimal in synthesis of aminooxy carbonyl compounds in high yields, with complete enantioselectivity not only for aldehydes but also for ketones.

Journal: :Chemical communications 2013
Ravi Kiran Chinnagolla Sandeep Pimparkar Masilamani Jeganmohan

The intramolecular halogenation of O-methylbenzohydroximoyl halides in the presence of a Ru catalyst and the ligand diphenylacetylene afforded halo substituted aromatic nitriles in a highly regioselective manner. Further, substituted nitriles were converted into substituted tetrazole derivatives in the presence of NaN3 and I2.

Journal: :Organometallics 2022

By the employment of 5-amino-1H-tetrazole and pyromellitic acid ligands to assemble with Zn2+ ions, a three-dimensional3,4-connect fry network {[Zn2(HATZ)(ATZ)2(PMA)0.5]·(H2O)5}n (GUPT-1, HATZ = 5-amino-1H-tetrazole, H4PMA acid) was isolated in hydrothermal reaction, which features high stability exhibits adsorption selectivity CO2/N2 (118) under ambient conditions 1 bar. Moreover, grand canoni...

Journal: :Acta Crystallographica Section E Structure Reports Online 2012

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