A new family of ring-annulated inositols with "locked" conformations has been designed to deliver a range of these biologically important entities in "unnatural conformations" while retaining their "natural configurations". The simple "tool" of trans ring fusion has been used to "lock" the conformation of the annulated inositols. Short, simple syntheses of a range of these novel cyclitols have ...

Water model experiments in an acrylic resin vessel have been performed to visualize evolution, growth, coalescence, vibration, and clustering of multi-cavitation bubbles in a standing plain wave at the frequency of about 42 kHz by using high-speed camera. Their dynamic behaviors are phenomenologically discussed in relation to the ultrasound field specified. Another experiment has also been carr...

The depletion-induced phase separation in a mixture of colloidal particles (PMMA-latex) and nonadsorbing polymers [poly(styrene)] in a solvent (mixture of tetralin, cis-decalin, and carbon tetrachloride) was investigated in real space with confocal scanning laser microscopy in the initial, intermediate, and final stage. It was found that the kinetics and the morphology of the phase separation s...

Serotonin-1A (5-HT(1A)) receptors in the CNS are a major target for psychotropic drugs. In nucleus raphe dorsalis (NRD) and hippocampus (CA3), the selective 5-HT(1A) agonist (+)-8-hydroxy-2-(di-N-propylamino) tetralin (8-OH-DPAT) reduces the firing activity of serotoninergic (5-HT) and pyramidal neurons, respectively. When located on 5-HT (autoreceptors), but not on non-5-HT (heteroreceptors) n...

(2002) Prefrontal dopamine D1 receptors and working memory in schizophrenia. A microdialysis study of the in vivo release of 5-HT in the median raphe nucleus of the rat. Br. (1989) An in vivo dialysis and behavioural study of the release of 5-HT by p-chloroamphetamine in reserpine-treated rats. Br. In vivo brain dialysis study of the somatodendritic release of serotonin in the raphe nuclei of t...

INTRODUCTION 'Legal highs' are psychoactive chemicals which are sold from 'head shops', the internet and from street suppliers and may be possessed without legal restriction. An increase in the marketing of these materials has resulted in a corresponding increase in published reports of their adverse effects. However, a lack of primary literature pertaining to their chemistry, pharmacology and ...

Methylenedioxymethamphetamine (MDMA) is a mood-altering, legally restricted drug that has been reported to inhibit glutamate-evoked firing of cells in the nucleus accumbens. This study used extracellular recording combined with microiontophoresis to examine whether the inhibitory effect of MDMA on neuronal firing in the nucleus accumbens is mediated by serotonin and/or dopamine. Serotonin and s...