Previous work indicates that the heavy chain of tetanus toxin is responsible for the binding of the toxin to the neuronal membrane and its subsequent internalization. In the present study, the light chain of tetanus toxin mimicked the holotoxin in inhibiting Ca2+-dependent secretion of [3H]norepinephrine from digitonin-permeabilized adrenal chromaffin cells. Preincubation of tetanus toxin with ...

OBJECTIVE To study the human teratogenic potential of tetanus vaccination during pregnancy. METHODS Pair analysis of cases with congenital abnormalities and matched healthy controls was performed in the large population-based dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1994. RESULTS Of 35 727 pregnant women who had babies without any defects in the s...

In this study, a formulation of Bordetella pertussis proteoliposome (PLBp), diphtheria, and tetanus toxoids and alum (DT-PLBp) was evaluated as a trivalent vaccine candidate in BALB/c mice. Vaccine-induced protection was estimated using the intranasal challenge for pertussis and enzyme-linked immunosorbent assay fvto assess serological responses for diphtheria or tetanus. Both, diphtheria-tetan...

Imunisasi Tetanus Toxoid (TT) merupakan program pemerintah untuk menurunkan angka penyakit tetanus. Khususnya calon pengantin (Catin) wanita agar terhindar dari kemungkinan terkena tetanus yang menyerang ibu dan bayi akibat persalinan dengan alat tidak steril. Strategi pelaksanaan imunisasi TT salah satu upaya Safe motherhood. Isu ini masih ditemukan pada bagian sosial Sustainable Development (...

background: vaccination against fatal viral and bacterial diseases is still the best protective way to lower morbidity and mortality rate in end‑stage renal disease (esrd) patients. it has been reported that there is high incidence of low protective levels of igg after vaccination in esrd adult patients. the aim of this study was to evaluate the protective status of vaccination against diphther...

background: immunization against diphtheria, tetanus and pertussis has been applied in iran since 1950. who suggests periodical evaluation of effectiveness of the triple diphtheria-tetanus-whole cell pertussis (dtwp) vaccine, worldwide. objectives: to determine the immunogenicity of locally manufactured dtwp vaccine administered to preschool children in a number of health centers of tehran in 2...

Background & Objective: Tetanus remains an important health problem in Kano, Northwestern Nigeria. It is associated with a high mortality rate, it is therefore necessary to identify predictors of mortality with the view to reducing the mortality rate. Methods: Demographic and clinical data of all adult tetanus patients managed at Aminu Kano Teaching Hospital and Murtala Muhammad Specialist Hosp...

BACKGROUND Autonomic nervous system (ANS) dysfunction is present in up to one third of patients with tetanus. The prognostic value of ANS dysfunction is known in severe tetanus but its value is not well established in mild to moderate tetanus. METHODS Medical records of all patients admitted with tetanus at two academic tertiary care centers in Karachi, Pakistan were reviewed. The demographic...

BACKGROUND There is a noticeable difference in serologic immune status against tetanus among different age and social groups in various countries due to different national vaccination policies and methods. OBJECTIVES Considering that the immunization status of trauma patients against tetanus is not-known or uncertain and they may need to receive the vaccine and tetabulin, this study was condu...

STUDY OBJECTIVE We determine tetanus seroprotection rates and physician compliance with tetanus prophylaxis recommendations among patients presenting with wounds. METHODS A prospective observational study of patients aged 18 years or older who presented to 5 university-affiliated emergency departments (EDs) because of wounds was conducted between March 1999 and August 2000. Serum antitoxin le...