In vitro and in vivo testosterone metabolism was studied using rat skin. The in vitro stoichiometric studies strongly suggested the existence in the skin of 5a-reductase and other enzymes involved in testosterone metabolism. The predominant metabolites were 5adihydrotestosterone, androstandiol and 6.4-androstenedione. The rate of testosterone metabolism in vitro was higher in preputial skin tha...

introduction: since discovery of high frequency waves, their biological effects have been in great attention. increased male fertility problems proposed their possible relation to use of microwaves. testes are of very active body tissues, which can be affected by these waves. age of exposure may also be an important factor. methods: this study was carried out to evaluated testosterone level in ...

OBJECTIVE It is generally accepted that SHBG decreases the bioavailability and activity of testosterone (T). In in vitro experiments increased levels of SHBG will be associated with decreased levels of non-SHBG bound testosterone (non-SHBG-T). However, in vivo SHBG can alter both production and clearance rates and thus plasma levels of T. DESIGN AND PATIENTS In order to study the effect of SH...

INTRODUCTION Data from animal, clinical and prevention studies support the role of androgens in prostate cancer growth, proliferation and progression. Results of serum based epidemiologic studies in humans, however, have been inconclusive. The present study aims to define whether serum testosterone can be used as a predictor of a posi¬tive second biopsy in males considered for re-biopsy. MATE...

the purpose of this research was to compare the effect of an exhaustive exercise session on the concentration of serum testosterone and cortisol and cortisol/testosterone ratio in the morning and the evening in female volleyball players. for this purpose, 12 female volleyball players (mean age 23.26 years, mean weight 58.8 kg, mean height 166.49 cm and at least four years of activity) participa...

Our goal in this study was to determine whether the urinary ratio of testosterone to luteinizing hormone (T/LH) as an indicator of exogenous anabolic steroid (AS) use is superior to the urinary ratio of testosterone to epitestosterone (T/E). After 2 weekly placebo injections, 19 subjects were given testosterone cypionate (TC) injections of 250 or 500 mg/week for 14 weeks followed by 14 weekly p...

I I N F A N T boys, a transient increase of gonadotropins, especially L H , occurs during the first months of life (1). A striking elevation of plasma androgens is associated wi th this increase (2). I n the same age group we also found enhanced testicular activity (3). Testicular testosterone concentrations were maximal in boys 1-3 months of age, wi th peak values similar to those in pubertal ...

PURPOSE To evaluate if late hormonal replacement is able to recover the prostatic tissue modified by androgenic deprivation. MATERIALS AND METHODS 24 rats were assigned into a Sham group; an androgen deficient group, submitted to bilateral orchiectomy (Orch); and a group submitted to bilateral orchiectomy followed by testosterone replacement therapy (Orch+T). After 60 days from surgery blood ...

Previous research has suggested a positive association between testosterone (T) and entrepreneurial behavior in males. However, this evidence was found in a study with a small sample size and has not been replicated. In the present study, we aimed to verify this association using two large, independent, population-based samples of males. We tested the association of T with entrepreneurial behav...