SALL4 (sal-like protein 4) is a pluripotency transcription factor, which is highly expressed in embryonic stem (ES) cells and which is essential for mouse preimplantation development. In adult mouse organs, Sall4 mRNA is highly expressed in the testis and ovary, while there is only little or no expression in other organs. There is also a high expression of SALL4 in human testicular germ cell tu...

Mammalian testis undergoes deep changes in their architecture and function during photoregression conditions in seasonal breeders. Particularly, the testicular mechanisms that regulate the transition between the active (functional) and inactive (regression) stage vary between species. The aim of the present study was to analyze the incidence of proliferation, apoptosis and autophagy in the test...

levofloxacin is one of the fluroquinoline antibiotic groups, which affect on controlling infections, especially in reproductive organs. it has therapeutic use in numerous countries, but little information exists on the effects of levofloxacin on spermatogenesis when it is used for infectious treatment. the current study was designed to determine whether levofloxacin influences testis tissue and...

Testis development from an indifferent gonad is a critical step in embryogenesis. A hallmark of testis differentiation is sex-specific vascularization that occurs as endothelial cells migrate from the adjacent mesonephros into the testis to surround Sertoli-germ cell aggregates and induce seminiferous cord formation. Many in vitro experiments have demonstrated that vascular endothelial growth f...

Mammalian testis is a target organ for thyroid hormones (Jannini et al., 1995; Aruldhas, 2002). Testis is an exocrine organ because it produces sperm and it is also an endocrine organ producing hormones (MendisHandagama, 2012). Histologically, the testis consists of three major cell types: Leydig cell (LCs) (steroidogenic cells), Sertoli cells (SCs) (nursery cells) and germ cells (GCs). LCs lie...

BACKGROUND In numerous Caudata, the testis is known to differentiate new lobes at adulthood, leading to a multiple testis. The Iberian ribbed newt Pleurodeles waltl has been studied extensively as a model for sex determination and differentiation. However, the evolution of its testis after metamorphosis is poorly documented. METHODS Testes were obtained from Pleurodeles waltl of different age...

Background: Experimentally induced diabetes in male rats is associated with alteration in functions of reproductive system. Acarbose, Pioglitazone and Repaglinide via decrease in blood glucose level can prevent the damage of testes. Materials and Methods: A total of 96 adult male albino rats whit a body weighing between 230- 250 g were injected by a single intraperitoneal injection of streptozo...

The manuscript deals with our studies and experiences in the assessment of cytoskeleton different cellular models situations. immunofluorescent study several cytoskeletal proteins was relevant evaluation a therapy for osteoarthritis, case alkaptonuria testing efficacy docetaxel neuroblastoma cancer cells leading to apoptosis. A part experience focus on seminiferous epithelium spermatozoa, ident...

The present investigation has been performed to obtain a complete distributional map of the oligosaccharidic component of the glycoconjugates in the testis of the human newborn. For this purpose seven eight HRP-conjugated lectins (SBA, DBA, PNA, WGA, OOA, UEAI, LTA and ConA) along with enzymatic treatments, were used. The Sertoli cells were characterized by the same sugar residues detected in t...

background: the predominant phytoestrogen in soy and derived products is the isoflavone genistein. genistein has antioxidant properties. morphine is a main psychoactive chemical in opium that can increase the generation of free radicals and therefore it could adversely affects the spermatogenesis. objective: the main goal was to investigate whether the genistein could protect morphine adverse e...